Table 2 Top SNP associations with plasma... | American Society of Hematology

Table 2

Top SNP associations with plasma tHcy concentration in GAIT and replication results in PROCARDIS

CHR	SNP	Position, kbp	Nearest gene*	A1	GAIT, n = 387			PROCARDIS, n = 1238
CHR	SNP	Position, kbp	Nearest gene*	A1	MAF, %	β	P	MAF, %	β	P†
1	rs1801133	11 779	MTHFR	G	39	0.11	9.30 × 10⁻⁵	36	0.12	.003
3	rs10934885	130 782	PLXND1	T	27	−0.13	2.10 × 10⁻⁵	22	−0.01	.905
5	rs7445013	71 734	ZNF366	A	45	−0.12	5.30 × 10⁻⁶	45	−0.11	.009
5	rs2338216	71 738	ZNF366	C	45	−0.13	3.30 × 10⁻⁶	45	−0.10	.011
5	rs4703872	71 759	ZNF366	C	45	−0.12	5.30 × 10⁻⁶	45	−0.10	.010
6	rs2071481	32 928	TAP1	T	12	−0.16	8.20 × 10⁻⁵	10	−0.06	.401
6	rs154986	32 987	HLA-DMB	G	10	0.17	7.60 × 10⁻⁵	7	−0.08	.328
7	rs2701039	107 411	LAMB1	G	34	−0.12	2.20 × 10⁻⁵	39	−0.07	.112
7	rs1559971	124 749		T	25	0.13	1.00 × 10⁻⁵	33	0.01	.765
7	rs7795867	124 765		T	19	0.13	5.40 × 10⁻⁵	25	0	.995
9	rs973117	8 990	PTPRD	C	33	0.11	5.50 × 10⁻⁶	36	0.09	.042
11	rs10488697	113 475	ZBTB16	A	11	0.17	2.20 × 10⁻⁵	8	0.07	.311
12	rs2190679	124 886		G	33	0.11	6.60 × 10⁻⁵	36	−0.02	.564
12	rs1859943	124 893		G	36	0.11	6.40 × 10⁻⁵	41	−0.01	.892
15	rs10162946	21 689		G	10	−0.19	2.00 × 10⁻⁵	13	0.02	.721
18	rs9962181	73 441	GALR1	T	13	0.14	9.20 × 10⁻⁵	10	−0.04	.547
19	rs2250066	56 221	KLK11	C	12	0.14	8.90 × 10⁻⁵	15	0	.945
21	rs2826520	21 085		C	33	−0.11	3.20 × 10⁻⁵	32	0.02	.725

CHR	SNP	Position, kbp	Nearest gene*	A1	GAIT, n = 387			PROCARDIS, n = 1238
CHR	SNP	Position, kbp	Nearest gene*	A1	MAF, %	β	P	MAF, %	β	P†
1	rs1801133	11 779	MTHFR	G	39	0.11	9.30 × 10⁻⁵	36	0.12	.003
3	rs10934885	130 782	PLXND1	T	27	−0.13	2.10 × 10⁻⁵	22	−0.01	.905
5	rs7445013	71 734	ZNF366	A	45	−0.12	5.30 × 10⁻⁶	45	−0.11	.009
5	rs2338216	71 738	ZNF366	C	45	−0.13	3.30 × 10⁻⁶	45	−0.10	.011
5	rs4703872	71 759	ZNF366	C	45	−0.12	5.30 × 10⁻⁶	45	−0.10	.010
6	rs2071481	32 928	TAP1	T	12	−0.16	8.20 × 10⁻⁵	10	−0.06	.401
6	rs154986	32 987	HLA-DMB	G	10	0.17	7.60 × 10⁻⁵	7	−0.08	.328
7	rs2701039	107 411	LAMB1	G	34	−0.12	2.20 × 10⁻⁵	39	−0.07	.112
7	rs1559971	124 749		T	25	0.13	1.00 × 10⁻⁵	33	0.01	.765
7	rs7795867	124 765		T	19	0.13	5.40 × 10⁻⁵	25	0	.995
9	rs973117	8 990	PTPRD	C	33	0.11	5.50 × 10⁻⁶	36	0.09	.042
11	rs10488697	113 475	ZBTB16	A	11	0.17	2.20 × 10⁻⁵	8	0.07	.311
12	rs2190679	124 886		G	33	0.11	6.60 × 10⁻⁵	36	−0.02	.564
12	rs1859943	124 893		G	36	0.11	6.40 × 10⁻⁵	41	−0.01	.892
15	rs10162946	21 689		G	10	−0.19	2.00 × 10⁻⁵	13	0.02	.721
18	rs9962181	73 441	GALR1	T	13	0.14	9.20 × 10⁻⁵	10	−0.04	.547
19	rs2250066	56 221	KLK11	C	12	0.14	8.90 × 10⁻⁵	15	0	.945
21	rs2826520	21 085		C	33	−0.11	3.20 × 10⁻⁵	32	0.02	.725

P values were adjusted for age, sex, smoking, BMI, and the MTHFR rs1801133 SNP.

CHR indicates chromosome; MAF, minor allele frequency; A1, major allele; and β, standardized β coefficient, obtained in the linear regression analyses.

No nearest gene given for SNPs more than 100 kbp from the closest protein-coding gene.

†

Adjusted for age, sex, smoking, BMI, country, and the MTHFR rs1801133 SNP. For the rs1801133 SNP, the above adjustments were applied, with the obvious exception of SNP rs1801133 itself.

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