Baseline characteristics of the GAIT and PROCARDIS study cohorts
| Characteristic . | GAIT study (n = 399) . | PROCARDIS study (n = 1238) . |
|---|---|---|
| Median age, y (range) | 37.7 (1-87) | 62 (57-66) |
| Women, no. (%) | 217 (54.4) | 236 (18.7) |
| Current smoker, no. (%) | 151 (37.8) | 708 (56.0) |
| Lipid-lowering treatment, no. (%) | 28 (7.0) | 910 (71.9) |
| Antihypertensive treatment, no. (%) | 30 (7.5) | 1010 (79.8) |
| Mean body mass index, kg/m2 (SD) | 24.8 (4.9) | 28.1 (4.12) |
| Mean HDL cholesterol (SD) | 1.42 (0.37) | 1.14 (0.29) |
| Mean LDL cholesterol (SD) | 3.27 (1.0) | 2.82 (0.81) |
| Mean triglycerides (SD) | 1.12 (0.88) | 1.87 (1.14) |
| Median fibrinogen, g/L (interquartile range) | 3.2 (1.6-5.8) | 3.7 (3.3-4.3) |
| Median homocysteine, total, mg/L (interquartile range) | 7.74 (2.7-23.8) | 12.2 (9.9-14.9) |
| Median estimated glomerular filtration rate, mL/min/kg2 (interquartile range) | NA | 74.8 (62-89) |
| Characteristic . | GAIT study (n = 399) . | PROCARDIS study (n = 1238) . |
|---|---|---|
| Median age, y (range) | 37.7 (1-87) | 62 (57-66) |
| Women, no. (%) | 217 (54.4) | 236 (18.7) |
| Current smoker, no. (%) | 151 (37.8) | 708 (56.0) |
| Lipid-lowering treatment, no. (%) | 28 (7.0) | 910 (71.9) |
| Antihypertensive treatment, no. (%) | 30 (7.5) | 1010 (79.8) |
| Mean body mass index, kg/m2 (SD) | 24.8 (4.9) | 28.1 (4.12) |
| Mean HDL cholesterol (SD) | 1.42 (0.37) | 1.14 (0.29) |
| Mean LDL cholesterol (SD) | 3.27 (1.0) | 2.82 (0.81) |
| Mean triglycerides (SD) | 1.12 (0.88) | 1.87 (1.14) |
| Median fibrinogen, g/L (interquartile range) | 3.2 (1.6-5.8) | 3.7 (3.3-4.3) |
| Median homocysteine, total, mg/L (interquartile range) | 7.74 (2.7-23.8) | 12.2 (9.9-14.9) |
| Median estimated glomerular filtration rate, mL/min/kg2 (interquartile range) | NA | 74.8 (62-89) |
The GAIT study19 was performed to investigate genetic susceptibility to idiopathic thrombophilia and the PROCARDIS study20,21 was performed to identify susceptibility genes for premature MI.
HDL indicates high-density lipoprotein; LDL, low-density lipoprotein; and NA, not available.