Table 2 131 I activity administered,... | American Society of Hematology

Table 2

¹³¹I activity administered, total radiation absorbed doses, and grade 3 or 4 regimen–related toxicities

Dose to liver (Gy), dose level	mCi ¹³¹I [MBq]	Dose to marrow, Gy	Dose to spleen, Gy	DLT/no. of patients treated
12	438 ± 209 (300-678)* [16 206 ± 7733 (11 100-25 086)]	24.8 ± 8.5 (17.2-33.9)	54.1 ± 3.2 (50.4-56.4)	0/3
14	325 ± 112 (246-404) [12 025 ± 4144 (9102-14 948)]	28.7 ± 13.6 (19.0-38.3)	109.6 ± 64.9 (63.7-155.5)	0/2
16	496 ± 114 (368-587) [18 352 ± 4218 (13 616-21 719)]	18.3 ± 3.8 (14.0-20.5)	59.7 ± 12.3 (45.6-68.2)	1/3
18	427 ± 23 (410-443) [15 799 ± 851 (15 710-16 391)]	24.1 ± 7.7 (18.7-29.5)	39.6†	0/2
20	605 ± 159 (334-841) [22 385 ± 5883 (12 358-31 117)]	25.1 ± 11.3 (6.3-41.3)	91.9 ± 27.4 (47.7-145.5)	3/12
22	513 ± 196 (296-932) [18 981 ± 7252 (10 952-34 484)]	33.0 ± 13.6 (5.2-45.9)	91.3 ± 30.0 (42.2-136.2)	3/9
24	629 ± 206 (319-1147) [23 273 ± 7622 (1183-42 439)]	36.1 ± 11.5 (14.6-48.0)	101.5 ± 34.4 (55.0-187.6)	4/21
26	735 ± 222 (510-1084) [27 195 ± 8214 (18 870-40 108)]	32.1 ± 10.7 (17.9-46.9)	108.4 ± 39.9 (45.2-145.3)	2/6

Dose to liver (Gy), dose level	mCi ¹³¹I [MBq]	Dose to marrow, Gy	Dose to spleen, Gy	DLT/no. of patients treated
12	438 ± 209 (300-678)* [16 206 ± 7733 (11 100-25 086)]	24.8 ± 8.5 (17.2-33.9)	54.1 ± 3.2 (50.4-56.4)	0/3
14	325 ± 112 (246-404) [12 025 ± 4144 (9102-14 948)]	28.7 ± 13.6 (19.0-38.3)	109.6 ± 64.9 (63.7-155.5)	0/2
16	496 ± 114 (368-587) [18 352 ± 4218 (13 616-21 719)]	18.3 ± 3.8 (14.0-20.5)	59.7 ± 12.3 (45.6-68.2)	1/3
18	427 ± 23 (410-443) [15 799 ± 851 (15 710-16 391)]	24.1 ± 7.7 (18.7-29.5)	39.6†	0/2
20	605 ± 159 (334-841) [22 385 ± 5883 (12 358-31 117)]	25.1 ± 11.3 (6.3-41.3)	91.9 ± 27.4 (47.7-145.5)	3/12
22	513 ± 196 (296-932) [18 981 ± 7252 (10 952-34 484)]	33.0 ± 13.6 (5.2-45.9)	91.3 ± 30.0 (42.2-136.2)	3/9
24	629 ± 206 (319-1147) [23 273 ± 7622 (1183-42 439)]	36.1 ± 11.5 (14.6-48.0)	101.5 ± 34.4 (55.0-187.6)	4/21
26	735 ± 222 (510-1084) [27 195 ± 8214 (18 870-40 108)]	32.1 ± 10.7 (17.9-46.9)	108.4 ± 39.9 (45.2-145.3)	2/6

Mean ± SD (range).

Estimated absorbed dose to spleen for 1 patient treated at the 18-Gy level; a second patient treated at this dose level had prior splenectomy.