Percentage of patients with the most common individual mutations in each of the disease phases
| Disease phase/mutation . | Percentage . |
|---|---|
| LBC/Ph+ ALL (n = 52) | |
| T315I | 21.2 |
| E255K | 19.2 |
| Y253H | 15.4 |
| G250E | 13.5 |
| E255V | 7.7 |
| F317L | 7.7 |
| M244V | 5.8 |
| F359V | 5.8 |
| E459K | 5.8 |
| MBC (n = 50) | |
| T315I | 16.0 |
| G250E | 14.0 |
| F486S | 12.0 |
| M244V | 10.0 |
| Q252H | 10.0 |
| M351T | 10.0 |
| H396R | 8.0 |
| L248V | 6.0 |
| Y253H | 6.0 |
| AP (n = 76) | |
| F359V | 14.5 |
| T315I | 13.2 |
| M351T | 13.2 |
| H396R | 10.5 |
| Y253H | 9.2 |
| M244V | 7.9 |
| G250E | 6.6 |
| E355G | 6.6 |
| Q252H | 5.3 |
| E255K | 5.3 |
| E279K | 5.3 |
| CP (n = 133) | |
| M351T | 16.5 |
| G250E | 12.0 |
| M244V | 11.3 |
| F359V | 9.8 |
| T315I | 7.5 |
| H396R | 7.5 |
| Y253H | 6.8 |
| F317L | 6.0 |
| E355G | 5.3 |
| Disease phase/mutation . | Percentage . |
|---|---|
| LBC/Ph+ ALL (n = 52) | |
| T315I | 21.2 |
| E255K | 19.2 |
| Y253H | 15.4 |
| G250E | 13.5 |
| E255V | 7.7 |
| F317L | 7.7 |
| M244V | 5.8 |
| F359V | 5.8 |
| E459K | 5.8 |
| MBC (n = 50) | |
| T315I | 16.0 |
| G250E | 14.0 |
| F486S | 12.0 |
| M244V | 10.0 |
| Q252H | 10.0 |
| M351T | 10.0 |
| H396R | 8.0 |
| L248V | 6.0 |
| Y253H | 6.0 |
| AP (n = 76) | |
| F359V | 14.5 |
| T315I | 13.2 |
| M351T | 13.2 |
| H396R | 10.5 |
| Y253H | 9.2 |
| M244V | 7.9 |
| G250E | 6.6 |
| E355G | 6.6 |
| Q252H | 5.3 |
| E255K | 5.3 |
| E279K | 5.3 |
| CP (n = 133) | |
| M351T | 16.5 |
| G250E | 12.0 |
| M244V | 11.3 |
| F359V | 9.8 |
| T315I | 7.5 |
| H396R | 7.5 |
| Y253H | 6.8 |
| F317L | 6.0 |
| E355G | 5.3 |
A total of 13% of patients had more than 1 of these mutations.