Biologic function and list of genes that had a 2-fold difference in expression after pdFVIII treatment relative to the HBSS-treated mice
| Functional grouping: gene function . | Gene name . | Gene symbol . | Intensity ratio (pdFVIII/HBSS) . |
|---|---|---|---|
| Cytokine-cytokine receptor interaction: binds IL-8 receptor and recruits DCs and neutrophils18 | Chemokine (C-X-C motif) ligand 2 | Cxcl2 | 3.13 |
| Cytokine-cytokine receptor interaction: induce type 2 T helper cell polarization and recruits natural killer (NK) cells; see Reference19 | Chemokine (C-C motif) ligand 2 | Ccl2 | 2.08 |
| Host defense to bacteria: inhibits actions of TNF-α18 | Proteoglycan 2 | Prg2 | 2.34 |
| Involved in septic shock: enhances inflammatory responses to microbial products20 | Triggering receptor expressed on myeloid cells 1 | Trem1 | 2.94 |
| Extracellular matrix protein: inhibits DC migration to lymph nodes21 | Secreted acidic cysteine-rich glycoprotein | Sparc | 0.47 |
| Heat shock protein (toll-like receptor [TLR] interacting protein): induce CD86 expression and release of TNF-α, IL-1β, and IL-622 | Heat shock protein 1A | Hspa1a | 3.03 |
| Heat shock protein: induce the infiltration of NK cells and DCs19 | Heat shock protein 1 | Hspb1 | 2.13 |
| Functional grouping: gene function . | Gene name . | Gene symbol . | Intensity ratio (pdFVIII/HBSS) . |
|---|---|---|---|
| Cytokine-cytokine receptor interaction: binds IL-8 receptor and recruits DCs and neutrophils18 | Chemokine (C-X-C motif) ligand 2 | Cxcl2 | 3.13 |
| Cytokine-cytokine receptor interaction: induce type 2 T helper cell polarization and recruits natural killer (NK) cells; see Reference19 | Chemokine (C-C motif) ligand 2 | Ccl2 | 2.08 |
| Host defense to bacteria: inhibits actions of TNF-α18 | Proteoglycan 2 | Prg2 | 2.34 |
| Involved in septic shock: enhances inflammatory responses to microbial products20 | Triggering receptor expressed on myeloid cells 1 | Trem1 | 2.94 |
| Extracellular matrix protein: inhibits DC migration to lymph nodes21 | Secreted acidic cysteine-rich glycoprotein | Sparc | 0.47 |
| Heat shock protein (toll-like receptor [TLR] interacting protein): induce CD86 expression and release of TNF-α, IL-1β, and IL-622 | Heat shock protein 1A | Hspa1a | 3.03 |
| Heat shock protein: induce the infiltration of NK cells and DCs19 | Heat shock protein 1 | Hspb1 | 2.13 |
Genes that had at least a 2-fold change in expression after rFVIII or pdFVIII infusion, respectively; all gene expression ratios are relative to HBSS-infused mice.