Table 1

ATRA induces expression of CCLs and CCRs in NB4 cells

Gene expression intensity before ATRA, AUMaximum gene expression intensity after ATRA, AUFold change
CCL2 71 10 285 151 
CCL22 18 1822 104 
CCL24 13 969 78 
CCL4 14 896 61 
CCL20 72 1441 21 
CCL3 181 3576 20 
CCL1 42 754 19 
CCL7 19 108 
CCR1 48 1331 28 
CCR2 41 851 21 
CCR3 25 489 19 
Gene expression intensity before ATRA, AUMaximum gene expression intensity after ATRA, AUFold change
CCL2 71 10 285 151 
CCL22 18 1822 104 
CCL24 13 969 78 
CCL4 14 896 61 
CCL20 72 1441 21 
CCL3 181 3576 20 
CCL1 42 754 19 
CCL7 19 108 
CCR1 48 1331 28 
CCR2 41 851 21 
CCR3 25 489 19 

mRNA expression of CCLs and CCRs was determined in total RNA from NB4 cells cultured with ATRA (10−6 M) for 0, 4, 8, 24, 48, 72, and 96 hours using the GeneChip Human Exon 1.0 ST Array. The table represents chemokines and receptors with at least 5-fold up-regulation of the gene expression intensity in arbitrary units (AUs) after ATRA treatment.

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