Table 2

Most significant GO categories that are correlated with miR-29 expression in primary AML samples

CountPBenjamini
GO categories enriched in genes that were negatively correlated with miR-29a and -29b expression    
    Annotation Cluster 1 (enrichment score 5.09)    
        Regulation of biologic process 163 <.001 0.009 
        Biologic regulation 175 <.001 0.005 
        Regulation of cellular process 152 <.001 0.005 
    Annotation Cluster 2 (enrichment score 4.76)    
        Cell death 44 <.001 0.005 
        Death 44 <.001 0.005 
        Apoptosis 42 <.001 0.005 
        Programmed cell death 42 <.001 0.006 
        Cell development 53 <.001 0.066 
GO categories enriched in genes that were negatively correlated only with miR-29b expression    
    Annotation Cluster 1 (enrichment score 5.27)    
        Posttranslational protein modification 69 <.001 0.013 
        Protein modification process 77 <.001 0.014 
        Biopolymer modification 78 <.001 0.005 
    Annotation Cluster 2 (enrichment score 3.25)    
        Protein metabolic process 124 <.001 0.092 
GO categories enriched in genes that were negatively correlated only with miR-29a expression    
    Annotation Cluster 1 (enrichment score 4.93)    
        Defense response 25 <.001 0.001 
        Immune response 27 <.001 0.140 
        Immune system process 31 <.001 0.120 
        Response to stimulus 52 0.016 0.980 
    Annotation Cluster 2 (enrichment score 4.93)    
        Defense response 25 <.001 0.001 
        Inflammatory response 15 <.001 0.045 
        Response to wounding 16 <.001 0.230 
        Response to external stimulus 19 .001 0.550 
        Response to stress 21 .051 1 
GO categories enriched in genes that were positively correlated only with miR-29b expression    
    Annotation Cluster 1 (enrichment score 13.5)    
        Intracellular organelle 379 <.001 <0.001 
        Organelle 379 <.001 <0.001 
        Intracellular membrane-bound organelle 339 <.001 <0.001 
        Membrane-bound organelle 339 <.001 <0.001 
    Annotation Cluster 2 (enrichment score 11.9)    
        Regulation of cellular process 223 <.001 <0.001 
        Regulation of biologic process 231 <.001 <0.001 
        Biologic regulation 244 <.001 <0.001 
    Annotation Cluster 3 (enrichment score 9.11)    
        Primary metabolic process 349 <.001 <0.001 
        Macromolecule metabolic process 311 <.001 <0.001 
        Cellular metabolic process 339 <.001 <0.001 
        Metabolic process 364 <.001 <0.001 
    Annotation Cluster 4 (enrichment score 6.9)    
        RNA metabolic process 157 <.001 <0.001 
        Regulation of metabolic process 152 <.001 <0.001 
        Regulation of cellular metabolic process 145 <.001 <0.001 
        Regulation of nucleic acid metabolic process 136 <.001 <0.001 
        Gene expression 175 <.001 <0.001 
        Transcription 137 <.001 <0.001 
        Regulation of gene expression 138 <.001 <0.001 
        Regulation of transcription, DNA-dependent 124 <.001 <0.001 
        Regulation of transcription 130 <.001 <0.001 
        Transcription, DNA-dependent 125 <.001 <0.001 
        RNA biosynthetic process 125 <.001 <0.001 
    Annotation Cluster 5 (enrichment score 6.34)    
        Zinc ion binding 124 <.001 <0.001 
        Transition metal ion binding 139 <.001 0.003 
    Annotation Cluster 6 (enrichment score 4.99)    
        Chromatin modification 23 <.001 <0.001 
        Establishment and/or maintenance of chromatin architecture 27 <.001 0.004 
        Chromosome organization and biogenesis 31 <.001 0.004 
        DNA packaging 27 <.001 0.005 
CountPBenjamini
GO categories enriched in genes that were negatively correlated with miR-29a and -29b expression    
    Annotation Cluster 1 (enrichment score 5.09)    
        Regulation of biologic process 163 <.001 0.009 
        Biologic regulation 175 <.001 0.005 
        Regulation of cellular process 152 <.001 0.005 
    Annotation Cluster 2 (enrichment score 4.76)    
        Cell death 44 <.001 0.005 
        Death 44 <.001 0.005 
        Apoptosis 42 <.001 0.005 
        Programmed cell death 42 <.001 0.006 
        Cell development 53 <.001 0.066 
GO categories enriched in genes that were negatively correlated only with miR-29b expression    
    Annotation Cluster 1 (enrichment score 5.27)    
        Posttranslational protein modification 69 <.001 0.013 
        Protein modification process 77 <.001 0.014 
        Biopolymer modification 78 <.001 0.005 
    Annotation Cluster 2 (enrichment score 3.25)    
        Protein metabolic process 124 <.001 0.092 
GO categories enriched in genes that were negatively correlated only with miR-29a expression    
    Annotation Cluster 1 (enrichment score 4.93)    
        Defense response 25 <.001 0.001 
        Immune response 27 <.001 0.140 
        Immune system process 31 <.001 0.120 
        Response to stimulus 52 0.016 0.980 
    Annotation Cluster 2 (enrichment score 4.93)    
        Defense response 25 <.001 0.001 
        Inflammatory response 15 <.001 0.045 
        Response to wounding 16 <.001 0.230 
        Response to external stimulus 19 .001 0.550 
        Response to stress 21 .051 1 
GO categories enriched in genes that were positively correlated only with miR-29b expression    
    Annotation Cluster 1 (enrichment score 13.5)    
        Intracellular organelle 379 <.001 <0.001 
        Organelle 379 <.001 <0.001 
        Intracellular membrane-bound organelle 339 <.001 <0.001 
        Membrane-bound organelle 339 <.001 <0.001 
    Annotation Cluster 2 (enrichment score 11.9)    
        Regulation of cellular process 223 <.001 <0.001 
        Regulation of biologic process 231 <.001 <0.001 
        Biologic regulation 244 <.001 <0.001 
    Annotation Cluster 3 (enrichment score 9.11)    
        Primary metabolic process 349 <.001 <0.001 
        Macromolecule metabolic process 311 <.001 <0.001 
        Cellular metabolic process 339 <.001 <0.001 
        Metabolic process 364 <.001 <0.001 
    Annotation Cluster 4 (enrichment score 6.9)    
        RNA metabolic process 157 <.001 <0.001 
        Regulation of metabolic process 152 <.001 <0.001 
        Regulation of cellular metabolic process 145 <.001 <0.001 
        Regulation of nucleic acid metabolic process 136 <.001 <0.001 
        Gene expression 175 <.001 <0.001 
        Transcription 137 <.001 <0.001 
        Regulation of gene expression 138 <.001 <0.001 
        Regulation of transcription, DNA-dependent 124 <.001 <0.001 
        Regulation of transcription 130 <.001 <0.001 
        Transcription, DNA-dependent 125 <.001 <0.001 
        RNA biosynthetic process 125 <.001 <0.001 
    Annotation Cluster 5 (enrichment score 6.34)    
        Zinc ion binding 124 <.001 <0.001 
        Transition metal ion binding 139 <.001 0.003 
    Annotation Cluster 6 (enrichment score 4.99)    
        Chromatin modification 23 <.001 <0.001 
        Establishment and/or maintenance of chromatin architecture 27 <.001 0.004 
        Chromosome organization and biogenesis 31 <.001 0.004 
        DNA packaging 27 <.001 0.005 
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