Differential diagnosis for HCL
| Disease . | Immunophenotype . | Other features . |
|---|---|---|
| HCL | CD11c, CD25, CD103, CD123, annexin A1+, CD20bright | Monocytopenia, frequent leukopenia |
| Hairy cell variant | CD11c, CD103, CD25− | No monocytopenia, high leukemic cell count |
| SMZL/SLVL | CD11c, CD25, CD24, CD79b | |
| Chronic lymphocytic leukemia | CD5, CD19, CD23 | |
| B-prolymphocytic leukemia | CD19, FMC7, CD79b, CD20, and CD22bright | High leukocyte count |
| Disease . | Immunophenotype . | Other features . |
|---|---|---|
| HCL | CD11c, CD25, CD103, CD123, annexin A1+, CD20bright | Monocytopenia, frequent leukopenia |
| Hairy cell variant | CD11c, CD103, CD25− | No monocytopenia, high leukemic cell count |
| SMZL/SLVL | CD11c, CD25, CD24, CD79b | |
| Chronic lymphocytic leukemia | CD5, CD19, CD23 | |
| B-prolymphocytic leukemia | CD19, FMC7, CD79b, CD20, and CD22bright | High leukocyte count |
SMZL/SLVL indicates splenic marginal zone lymphoma/splenic lymphoma with villous lymphocytes. This entity may occasionally be CD103+. In addition, CD11c has also been reported to be positive in a subset of these patients.