Relative and absolute fold reductions of progenitor cells and DCs in knockout mice compared with WT mice
| Cell population . | GM-CSF−/− . | FL−/− . | DKO . |
|---|---|---|---|
| MDPΔ | 1.0/1.5 | 1.3*/2.3* | 2.9*/7.1* |
| CDP | 1.0/1.5 | 1.3*/1.9* | 2.4*/4.6* |
| Spleen cDC | 1.7*/1.8 | 5.7*/7.5* | 4.9*/7.0* |
| Spleen pDC | 1.2/0.8 | 6.2*/5.6* | 6.7*/9.9* |
| LN cDC | 3.4*/4.0* | 28*/8.3* | 7.5*/41.6* |
| LN pDC | 1.4/1.8 | 10.9*/7.5* | 19.4*/79* |
| LN CD40hiCD11cint DC | 1.8/2.3 | 1.5/2.3 | 3.3*/8.3* |
| CD45+MHCII+ dermal DC | 1.4*/ND | 2.2*/ND | 4.8*/ND |
| LC | ND/2.0* | ND/1.3* | ND/1.5* |
| Cell population . | GM-CSF−/− . | FL−/− . | DKO . |
|---|---|---|---|
| MDPΔ | 1.0/1.5 | 1.3*/2.3* | 2.9*/7.1* |
| CDP | 1.0/1.5 | 1.3*/1.9* | 2.4*/4.6* |
| Spleen cDC | 1.7*/1.8 | 5.7*/7.5* | 4.9*/7.0* |
| Spleen pDC | 1.2/0.8 | 6.2*/5.6* | 6.7*/9.9* |
| LN cDC | 3.4*/4.0* | 28*/8.3* | 7.5*/41.6* |
| LN pDC | 1.4/1.8 | 10.9*/7.5* | 19.4*/79* |
| LN CD40hiCD11cint DC | 1.8/2.3 | 1.5/2.3 | 3.3*/8.3* |
| CD45+MHCII+ dermal DC | 1.4*/ND | 2.2*/ND | 4.8*/ND |
| LC | ND/2.0* | ND/1.3* | ND/1.5* |
Values are the mean relative fold reduction/absolute fold reduction. DKO indicates double knockout; and ND, not determined.
Significant reduction compared with WT (P < .05).