Table 3 Risk of MGUS by relative and... | American Society of Hematology

Table 3

Risk of MGUS by relative and proband characteristics

Relative or proband characteristic	All probands (MGUS and MM)					MGUS probands			MM probands
Relative or proband characteristic	Total no.	Observed/expected MGUS cases	Risk ratio*	95% CI	P†	Risk ratio*	95% CI	P†	Riskratio*	95% CI	P†
Variables in first-degree relatives
Younger than 65 y	587	19/7.75	2.45	(1.55-3.81)		2.28	(0.94-5.43)		2.52	(1.48-4.21)
65 y or older	324	36/15.19	2.37	(1.66-3.18)	.84	3.71	(2.23-5.76)	.37	1.79	(1.11-2.72)	.30
Female	529	28/11.32	2.47	(1.68-3.51)		3.89	(2.11-6.89)		2.00	(1.22-3.16)
Male	382	27/11.62	2.32	(1.55-3.29)	.79	2.79	(1.49-4.87)	.42	2.08	(1.24-3.31)	.93
Parent/child	418	17/8.44	2.01	(1.22-3.16)		2.34	(0.96-5.57)		1.90	(1.05, 3.25)
Sibling	493	38/14.50	2.62	(1.86-3.52)	.36	3.66	(2.20-5.70)	.40	2.13	(1.36–3.21)	.73
Variables in probands
Proband younger than 65 y	553	29/13.51	2.15	(1.46-3.02)		2.23	(0.98-4.86)		2.13	(1.38-3.12)
Proband 65 y or older	358	26/9.43	2.76	(1.83-3.94)	.36	3.92	(2.33-6.20)	.25	1.87	(0.98-3.40)	.74
M spike less than 1.5	397	18/9.92	1.81	(1.12-2.82)		2.83	(1.60-4.75)		0.94	(0.38-2.21)
M spike 1.5 or more	514	37/13.02	2.84	(2.01-3.82)	.12	4.12	(2.09-7.70)	.39	2.58	(1.74-3.65)	.04
IgG	587	38/15.0	2.53	(1.80-3.40)		2.50	(1.42-4.20)		2.55	(1.68-3.68)
Other‡	324	17/7.94	2.14	(1.30-3.36)	.56	5.68	(2.87-10.61)	.06	1.26	(0.62-2.46)	.08

Relative or proband characteristic	All probands (MGUS and MM)					MGUS probands			MM probands
Relative or proband characteristic	Total no.	Observed/expected MGUS cases	Risk ratio*	95% CI	P†	Risk ratio*	95% CI	P†	Riskratio*	95% CI	P†
Variables in first-degree relatives
Younger than 65 y	587	19/7.75	2.45	(1.55-3.81)		2.28	(0.94-5.43)		2.52	(1.48-4.21)
65 y or older	324	36/15.19	2.37	(1.66-3.18)	.84	3.71	(2.23-5.76)	.37	1.79	(1.11-2.72)	.30
Female	529	28/11.32	2.47	(1.68-3.51)		3.89	(2.11-6.89)		2.00	(1.22-3.16)
Male	382	27/11.62	2.32	(1.55-3.29)	.79	2.79	(1.49-4.87)	.42	2.08	(1.24-3.31)	.93
Parent/child	418	17/8.44	2.01	(1.22-3.16)		2.34	(0.96-5.57)		1.90	(1.05, 3.25)
Sibling	493	38/14.50	2.62	(1.86-3.52)	.36	3.66	(2.20-5.70)	.40	2.13	(1.36–3.21)	.73
Variables in probands
Proband younger than 65 y	553	29/13.51	2.15	(1.46-3.02)		2.23	(0.98-4.86)		2.13	(1.38-3.12)
Proband 65 y or older	358	26/9.43	2.76	(1.83-3.94)	.36	3.92	(2.33-6.20)	.25	1.87	(0.98-3.40)	.74
M spike less than 1.5	397	18/9.92	1.81	(1.12-2.82)		2.83	(1.60-4.75)		0.94	(0.38-2.21)
M spike 1.5 or more	514	37/13.02	2.84	(2.01-3.82)	.12	4.12	(2.09-7.70)	.39	2.58	(1.74-3.65)	.04
IgG	587	38/15.0	2.53	(1.80-3.40)		2.50	(1.42-4.20)		2.55	(1.68-3.68)
Other‡	324	17/7.94	2.14	(1.30-3.36)	.56	5.68	(2.87-10.61)	.06	1.26	(0.62-2.46)	.08

Compared with reference population.

Comparison of risk ratios between groups for each variable.

Other category consists of IgA, IgM, light chain, and other combined.