Table 5 Multivariate analysis (Cox... | American Society of Hematology

Table 5

Multivariate analysis (Cox regression) on the DFS and OS

Variable	DFS, 95% CI				OS, 95% CI
Variable	RR	Lower	Upper	P	RR	Lower	Upper	P
Age†	1.520	1.145	2.017	.004*	2.682	1.867	3.853	< .001*
Karyotype	2.104	1.625	2.724	< .001*	2.325	1.638	3.300	< .001*
LDH‡	1.203	0.895	1.616	.221	1.487	1.018	2.173	.040*
WBC§	1.336	0.973	1.834	.073	1.583	1.077	2.325	.019*
RUNX1	1.426	0.922	2.207	.111	1.878	1.109	3.179	.019*
CEBPA	0.420	0.274	0.644	< .001*	0.423	0.240	0.746	.003*
NPM1/FLT3-ITD‖	0.282	0.156	0.510	< .001*	0.276	0.132	0.578	.001*
WT1	1.861	1.204	2.877	.005*	2.155	1.219	3.809	.008*

Variable	DFS, 95% CI				OS, 95% CI
Variable	RR	Lower	Upper	P	RR	Lower	Upper	P
Age†	1.520	1.145	2.017	.004*	2.682	1.867	3.853	< .001*
Karyotype	2.104	1.625	2.724	< .001*	2.325	1.638	3.300	< .001*
LDH‡	1.203	0.895	1.616	.221	1.487	1.018	2.173	.040*
WBC§	1.336	0.973	1.834	.073	1.583	1.077	2.325	.019*
RUNX1	1.426	0.922	2.207	.111	1.878	1.109	3.179	.019*
CEBPA	0.420	0.274	0.644	< .001*	0.423	0.240	0.746	.003*
NPM1/FLT3-ITD‖	0.282	0.156	0.510	< .001*	0.276	0.132	0.578	.001*
WT1	1.861	1.204	2.877	.005*	2.155	1.219	3.809	.008*

Statistically significant (P < .05).

Age older than 50 years relative to age 50 years or younger (reference value).

LDH greater than 920 U/L versus less than 920 U/L.

WBC greater than 50 × 10⁹/L versus less than 50 × 10⁹/L.

NPM1mutant/FLT3-ITD− versus other subtypes.