Association of RUNX1 mutation with chromosomal abnormalities*
| Variable . | Total . | RUNX1-mutated . | RUNX1-wild . | P . |
|---|---|---|---|---|
| Karyotype† | < .001 | |||
| Favorable | 59 | 0 (0.0) | 59 (100.0) | |
| Intermediate | 327 | 48 (14.7) | 279 (85.3) | |
| Unfavorable | 66 | 8 (12.1) | 58 (87.9) | |
| Unknown | 18 | 6 (33.3) | 12 (66.7) | |
| Normal | 230 | 32 (13.9) | 198 (86.1) | = .622 |
| Simple | 169 | 19 (11.2) | 150 (88.8) | |
| Complex | 53 | 5 (9.4) | 48 (90.6) | |
| t(8;21) | 40 | 0 (0.0) | 40 (100.0) | = .009 |
| inv(16) | 19 | 0 (0.0) | 19 (100.0) | .149 |
| t(11q23) | 16 | 0 (0.0) | 16 (100.0) | = .239 |
| −5/5q-‡ | 1 | 0 (0.0) | 1 (100.0) | > .999 |
| −7/7q-‡ | 10 | 3 (30.0) | 7 (70.0) | = .115 |
| +8‡ | 22 | 6 (27.3) | 16 (72.7) | = .042 |
| +11‡ | 3 | 0 (0.0) | 3 (100.0) | > .999 |
| +13‡ | 1 | 0 (0.0) | 1 (100.0) | > .999 |
| +21‡ | 11 | 2 (18.2) | 9 (81.8) | .634 |
| Variable . | Total . | RUNX1-mutated . | RUNX1-wild . | P . |
|---|---|---|---|---|
| Karyotype† | < .001 | |||
| Favorable | 59 | 0 (0.0) | 59 (100.0) | |
| Intermediate | 327 | 48 (14.7) | 279 (85.3) | |
| Unfavorable | 66 | 8 (12.1) | 58 (87.9) | |
| Unknown | 18 | 6 (33.3) | 12 (66.7) | |
| Normal | 230 | 32 (13.9) | 198 (86.1) | = .622 |
| Simple | 169 | 19 (11.2) | 150 (88.8) | |
| Complex | 53 | 5 (9.4) | 48 (90.6) | |
| t(8;21) | 40 | 0 (0.0) | 40 (100.0) | = .009 |
| inv(16) | 19 | 0 (0.0) | 19 (100.0) | .149 |
| t(11q23) | 16 | 0 (0.0) | 16 (100.0) | = .239 |
| −5/5q-‡ | 1 | 0 (0.0) | 1 (100.0) | > .999 |
| −7/7q-‡ | 10 | 3 (30.0) | 7 (70.0) | = .115 |
| +8‡ | 22 | 6 (27.3) | 16 (72.7) | = .042 |
| +11‡ | 3 | 0 (0.0) | 3 (100.0) | > .999 |
| +13‡ | 1 | 0 (0.0) | 1 (100.0) | > .999 |
| +21‡ | 11 | 2 (18.2) | 9 (81.8) | .634 |
A total of 452 patients, including 56 RUNX1-mutated and 396 RUNX1-wild patients, had chromosome data at diagnosis.
Favorable consists of t(15;17), t(8;21), inv (16); unfavorable, −7, del(7q), −5, del(5q), 3q abnormality, complex abnormalities; and intermediate, normal karyotype and other abnormalities.
Includes only simple chromosomal abnormalities with 2 or fewer changes, but not those with complex abnormalities with 3 or more aberrations. There was no association of RUNX1 mutations with any of these chromosome changes, including +8, when complex abnormalities were also included in the analysis.