Table 2

Comparison of clinical manifestation and laboratory features between AML patients with and without RUNX1 mutation

VariableTotal (n = 470)RUNX1-mutated* (n = 62, 13.2%)RUNX1-wild (n = 408, 86.8%)P
Sex, no. (%) of patients    < .001 
    Male 266 49 (18.4) 217 (81.6)  
    Female 204 13 (6.4) 191 (93.6)  
Median age, y (range) 52.0 (15-90) 62.0 (15-89) 48.0 (15-90) = .010 
Laboratory data, median (range)     
    WBC (/μL) 21 850 (120-627800) 15 225 (310-258900) 22 430 (120-627800) = .184 
    Hemoglobin, g/dL 8.0 (2.9-16.2) 7.8 (3.8-11.9) 8.0 (2.9-16.2) = .855 
    Platelets, × 1000/μL 45.0 (3-802) 49.5 (3-202) 43.0 (3-802) = .584 
    Blasts, per μL 9863 (0-456 725) 7535 (102-246 602) 10 015 (0-456 725) = .643 
    LDH, U/L 890 (206-15 000) 733 (299-8116) 918 (206-15 000) = .003 
FAB, no. (%) of patients    = .004 
    M0 10 4 (40.0) 6 (60.0)  
    M1 114 20 (17.5) 94 (82.5)  
    M2 174 11 (6.3) 163 (93.7)  
    M4 126 19 (15.1) 107 (84.9)  
    M5 25 4 (16.0) 21 (84.0)  
    M6 12 3 (25.0) 9 (75.0)  
    Undetermined 1 (11.1) 8 (88.9)  
    Induction response* 330 37 293 = .006 
    CR 248 (75.2) 21 (56.8) 227 (77.5)  
    PR 13 (3.9) 5 (13.5) 8 (2.7)  
    Refractory 46 (13.9) 7 (18.9) 39 (13.3)  
    Induction death 23 (7.0) 4 (10.8) 19 (6.5)  
VariableTotal (n = 470)RUNX1-mutated* (n = 62, 13.2%)RUNX1-wild (n = 408, 86.8%)P
Sex, no. (%) of patients    < .001 
    Male 266 49 (18.4) 217 (81.6)  
    Female 204 13 (6.4) 191 (93.6)  
Median age, y (range) 52.0 (15-90) 62.0 (15-89) 48.0 (15-90) = .010 
Laboratory data, median (range)     
    WBC (/μL) 21 850 (120-627800) 15 225 (310-258900) 22 430 (120-627800) = .184 
    Hemoglobin, g/dL 8.0 (2.9-16.2) 7.8 (3.8-11.9) 8.0 (2.9-16.2) = .855 
    Platelets, × 1000/μL 45.0 (3-802) 49.5 (3-202) 43.0 (3-802) = .584 
    Blasts, per μL 9863 (0-456 725) 7535 (102-246 602) 10 015 (0-456 725) = .643 
    LDH, U/L 890 (206-15 000) 733 (299-8116) 918 (206-15 000) = .003 
FAB, no. (%) of patients    = .004 
    M0 10 4 (40.0) 6 (60.0)  
    M1 114 20 (17.5) 94 (82.5)  
    M2 174 11 (6.3) 163 (93.7)  
    M4 126 19 (15.1) 107 (84.9)  
    M5 25 4 (16.0) 21 (84.0)  
    M6 12 3 (25.0) 9 (75.0)  
    Undetermined 1 (11.1) 8 (88.9)  
    Induction response* 330 37 293 = .006 
    CR 248 (75.2) 21 (56.8) 227 (77.5)  
    PR 13 (3.9) 5 (13.5) 8 (2.7)  
    Refractory 46 (13.9) 7 (18.9) 39 (13.3)  
    Induction death 23 (7.0) 4 (10.8) 19 (6.5)  
*

Only the patients with distinct RUNX1 mutations were included in this group. Those with insignificant mutations, such as G42R, D317N, Q370R, V425G, and M439L, were excluded.