Target-to-blood ratios and measured activities of 131I-BC8-FP and 125I-BC8-Ab coinjected 96 hours before tissue harvest
| Experiment/organ . | BC8-FP . | SD . | BC8-Ab . | SD . |
|---|---|---|---|---|
| Experiment 2 | ||||
| LN | 0.093% | ± 0.020% | 0.046% | ± 0.013% |
| Spleen | 0.158% | ± 0.00% | 0.057% | ± 0.00% |
| Kidney | 0.016% | ± 0.001% | 0.003% | ± 0.000% |
| Liver | 0.015% | ± 0.000% | 0.005% | ± 0.001% |
| Lung | 0.008% | ± 0.002% | 0.007% | ± 0.001% |
| LN:blood | 4:1 | — | 1.3:1 | — |
| Spleen:blood | 6.9:1 | — | 1.5:1 | — |
| BM:blood | 0.8:1 | — | 0.4:1 | — |
| Experiment 3 | ||||
| LN | 0.141% | ± 0.031% | 0.075% | ± 0.019% |
| Spleen | 0.160% | ± 0.001% | 0.070% | ± 0.001% |
| Kidney | 0.027% | ± 0.001% | 0.016% | ± 0.002% |
| Liver | 0.016% | ± 0.001% | 0.010% | ± 0.001% |
| Lung | 0.025% | ± 0.005% | 0.025% | ± 0.003% |
| LN:blood | 4:1 | — | 1.4:1 | — |
| Spleen:blood | 4.7:1 | — | 1.3:1 | — |
| BM:blood | 1.7:1 | — | 0.92:1 | — |
| Experiment/organ . | BC8-FP . | SD . | BC8-Ab . | SD . |
|---|---|---|---|---|
| Experiment 2 | ||||
| LN | 0.093% | ± 0.020% | 0.046% | ± 0.013% |
| Spleen | 0.158% | ± 0.00% | 0.057% | ± 0.00% |
| Kidney | 0.016% | ± 0.001% | 0.003% | ± 0.000% |
| Liver | 0.015% | ± 0.000% | 0.005% | ± 0.001% |
| Lung | 0.008% | ± 0.002% | 0.007% | ± 0.001% |
| LN:blood | 4:1 | — | 1.3:1 | — |
| Spleen:blood | 6.9:1 | — | 1.5:1 | — |
| BM:blood | 0.8:1 | — | 0.4:1 | — |
| Experiment 3 | ||||
| LN | 0.141% | ± 0.031% | 0.075% | ± 0.019% |
| Spleen | 0.160% | ± 0.001% | 0.070% | ± 0.001% |
| Kidney | 0.027% | ± 0.001% | 0.016% | ± 0.002% |
| Liver | 0.016% | ± 0.001% | 0.010% | ± 0.001% |
| Lung | 0.025% | ± 0.005% | 0.025% | ± 0.003% |
| LN:blood | 4:1 | — | 1.4:1 | — |
| Spleen:blood | 4.7:1 | — | 1.3:1 | — |
| BM:blood | 1.7:1 | — | 0.92:1 | — |
— indicates not applicable.
In experiments 2 and 3, equimolar doses (8.45 nmol/kg) of 125I-BC8-Ab and 131I-BC8-FP were coinjected. Organ tissues were harvested at necropsy and performed 96 hours after injection of the reagents. The contents of the trace-labeled reagents in tissue specimens were measured in a dual-channel gamma counter and are expressed as the percentage injected dose per gram of tissue (%ID/g). SDs reflect 3 biopsy specimens from each tissue.