Molecular pathways implicated in HSC-niche interactions
| Calcium-sensing receptor19 |
| Parathyroid hormone receptor25 (potentially as a function of increased osteoblast numbers) |
| Bone morphogenic protein receptor 1A21 (also potentially as a function of increased osteoblast numbers) |
| Osteopontin24,34 |
| CX chemokine ligand 12 (also known as stromal-derived factor-1)–CX chemokine receptor 4 interactions43,45 |
| Angiopoietin-Tie2 interactions58 |
| Canonical Wnt signaling26 |
| Notch activation (with osteoblast parathyroid hormone receptor activation)25 |
| Mpl receptor, thrombopoietin53 |
| cKit receptor, stem cell factor (SCF)37 |
| Cdc4259 and Rac proteins55 |
| Insulin-like growth factor 260 |
| N-cadherin (conflicting data exist)21,32,36 |
| VLA-450 |
| VCAM-145 |
| Calcium-sensing receptor19 |
| Parathyroid hormone receptor25 (potentially as a function of increased osteoblast numbers) |
| Bone morphogenic protein receptor 1A21 (also potentially as a function of increased osteoblast numbers) |
| Osteopontin24,34 |
| CX chemokine ligand 12 (also known as stromal-derived factor-1)–CX chemokine receptor 4 interactions43,45 |
| Angiopoietin-Tie2 interactions58 |
| Canonical Wnt signaling26 |
| Notch activation (with osteoblast parathyroid hormone receptor activation)25 |
| Mpl receptor, thrombopoietin53 |
| cKit receptor, stem cell factor (SCF)37 |
| Cdc4259 and Rac proteins55 |
| Insulin-like growth factor 260 |
| N-cadherin (conflicting data exist)21,32,36 |
| VLA-450 |
| VCAM-145 |