Patient demographics
| Patient characteristics . | Single unit (n = 84), no. (%) . | Double unit (n = 93), no. (%) . | P . |
|---|---|---|---|
| Year of transplant | |||
| 1994-2000 | 34 (41%) | 1 (1%) | < .01 |
| 2000-2008 | 50 (59%) | 92 (99%) | |
| Age, y | |||
| Less than 18 | 68 (81%) | 21 (23%) | < .01 |
| 18 | 16 (17%) | 72 (77%) | |
| Median (range) | 8 (0.5-52) | 24 (9-57) | |
| Median recipient weight, kg (range) | 32 (9-108) | 69 (32-149) | < .01 |
| Male recipients | 48 (57%) | 50 (54%) | .65 |
| Positive recipient CMV status | 38 (45%) | 53 (57%) | .12 |
| Median time from diagnosis to transplant, CR1 (range) | 4.1 (2.2-35.5) | 3.9 (2.2-11.3) | .47 |
| Median length of remission, CR2 (range) | 15.1 (0.8-67.3) | 21.2 (0.9-117.3) | .38 |
| Disease | |||
| ALL | 48 (57%) | 40 (43%) | .09 |
| ALL, CR1-2 | 27 (32%) | 35 (38%) | |
| ALL, CR3-rel | 13 (15%) | 5 (0.5%) | |
| AML | 34 (43%) | 53 (57%) | .36 |
| AML, CR1-2 | 27 (32%) | 44 (47%) | |
| AML, CR3-rel | 9 (11%) | 9 (9.5%) | |
| High-risk CR1 | 19/22 (86%) | 38/44 (86%) | .99 |
| Induction failure | 1 | 8 | |
| Prior MDS or 5q or 7− | 5 | 6 | |
| t(9:22) | 7 | 7 | |
| Bilineage leukemia | 1 | ||
| 5 or more cytogenetic changes | 1 | ||
| FLT3-ITD | 1 | ||
| 11q23 | 4 | 12 | |
| Hypodiploidy, for ALL | 1 | ||
| WBC more than 50 000/mm3 at diagnosis, for ALL | 1 | 2 |
| Patient characteristics . | Single unit (n = 84), no. (%) . | Double unit (n = 93), no. (%) . | P . |
|---|---|---|---|
| Year of transplant | |||
| 1994-2000 | 34 (41%) | 1 (1%) | < .01 |
| 2000-2008 | 50 (59%) | 92 (99%) | |
| Age, y | |||
| Less than 18 | 68 (81%) | 21 (23%) | < .01 |
| 18 | 16 (17%) | 72 (77%) | |
| Median (range) | 8 (0.5-52) | 24 (9-57) | |
| Median recipient weight, kg (range) | 32 (9-108) | 69 (32-149) | < .01 |
| Male recipients | 48 (57%) | 50 (54%) | .65 |
| Positive recipient CMV status | 38 (45%) | 53 (57%) | .12 |
| Median time from diagnosis to transplant, CR1 (range) | 4.1 (2.2-35.5) | 3.9 (2.2-11.3) | .47 |
| Median length of remission, CR2 (range) | 15.1 (0.8-67.3) | 21.2 (0.9-117.3) | .38 |
| Disease | |||
| ALL | 48 (57%) | 40 (43%) | .09 |
| ALL, CR1-2 | 27 (32%) | 35 (38%) | |
| ALL, CR3-rel | 13 (15%) | 5 (0.5%) | |
| AML | 34 (43%) | 53 (57%) | .36 |
| AML, CR1-2 | 27 (32%) | 44 (47%) | |
| AML, CR3-rel | 9 (11%) | 9 (9.5%) | |
| High-risk CR1 | 19/22 (86%) | 38/44 (86%) | .99 |
| Induction failure | 1 | 8 | |
| Prior MDS or 5q or 7− | 5 | 6 | |
| t(9:22) | 7 | 7 | |
| Bilineage leukemia | 1 | ||
| 5 or more cytogenetic changes | 1 | ||
| FLT3-ITD | 1 | ||
| 11q23 | 4 | 12 | |
| Hypodiploidy, for ALL | 1 | ||
| WBC more than 50 000/mm3 at diagnosis, for ALL | 1 | 2 |