American Society of Hematology

Table 3

Distribution of MolR according to CBA and I-FISH data

		Molecular response
		Major MolR, n (%)	P	Median BCR-ABL transcripts level*	P
Cytogenetic response by I-FISH and by CBA	No Ph⁺ metaphases and < 1% BCR-ABL⁺ nuclei (n = 425)	281 (66.1)		0.035
			.004		.06
	No Ph⁺ metaphases but ≥ 1% BCR-ABL⁺ nuclei (n = 87)	43 (49.4)		0.079
Cytogenetic response by I-FISH	No BCR-ABL⁺ nuclei (n = 396)	263 (66.4)		0.031
			.68		.43
	0.1%-0.9% BCR-ABL⁺ nuclei (n = 29)	21 (72.4)		0.043
			< .001		< .001
	1%-5% BCR-ABL⁺ nuclei (n = 95)	49 (51.6)		0.082

		Molecular response
		Major MolR, n (%)	P	Median BCR-ABL transcripts level*	P
Cytogenetic response by I-FISH and by CBA	No Ph⁺ metaphases and < 1% BCR-ABL⁺ nuclei (n = 425)	281 (66.1)		0.035
			.004		.06
	No Ph⁺ metaphases but ≥ 1% BCR-ABL⁺ nuclei (n = 87)	43 (49.4)		0.079
Cytogenetic response by I-FISH	No BCR-ABL⁺ nuclei (n = 396)	263 (66.4)		0.031
			.68		.43
	0.1%-0.9% BCR-ABL⁺ nuclei (n = 29)	21 (72.4)		0.043
			< .001		< .001
	1%-5% BCR-ABL⁺ nuclei (n = 95)	49 (51.6)		0.082

CBA indicates chromosome banding analysis; I-FISH, interphase fluorescence in situ hybridization; and MolR, molecular response.

BCR-ABL/ABL% on the international scale.