Outcomes for the 7 patients with CNS thrombosis (none treated with prophylactic AT or FG replacement)
| . | Patient no. . | ||||||
|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | |
| Leukemia risk | High | High | High | Standard | High | High | High |
| Location of thrombosis | Sagittal sinus | Sagittal sinus | Sagittal sinus | Sagittal sinus | Left transverse sinus | Sagittal sinus | Sagittal sinus |
| Phase of therapy | Induction | Induction | Induction | Induction | Induction | Induction | Induction |
| Symptoms | Focal and generalized seizures, headaches, vomiting | Focal seizures, headaches, vomiting | Generalized seizures | Generalized seizures | Generalized seizures | Generalized seizures, unilateral weakness | Focal seizures, unilateral weakness, motor dysphagia |
| Primary treatment | LMWH | LMWH | Heparin | None | LMWH | Heparin | LMWH |
| Secondary treatment | Warfarin | Warfarin | Warfarin | None | None | LMWH | None |
| Thrombosis outcome | Persistence of clot | Partial resolution of clot | Resolution of clot | Resolution of clot | Resolution of clot | Resolution of clot | Partial resolution of clot |
| Symptoms outcome | Resolved | Resolved | Resolved | Resolved | Resolved | Resolved | Resolved |
| ASP | Continued | Continued | Continued | Discontinued | Continued | Continued | Continued |
| Leukemia outcome | CR1 | CR1 | CR1 | CR1 | CR1 | CR1 | CR2 |
| . | Patient no. . | ||||||
|---|---|---|---|---|---|---|---|
| 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | |
| Leukemia risk | High | High | High | Standard | High | High | High |
| Location of thrombosis | Sagittal sinus | Sagittal sinus | Sagittal sinus | Sagittal sinus | Left transverse sinus | Sagittal sinus | Sagittal sinus |
| Phase of therapy | Induction | Induction | Induction | Induction | Induction | Induction | Induction |
| Symptoms | Focal and generalized seizures, headaches, vomiting | Focal seizures, headaches, vomiting | Generalized seizures | Generalized seizures | Generalized seizures | Generalized seizures, unilateral weakness | Focal seizures, unilateral weakness, motor dysphagia |
| Primary treatment | LMWH | LMWH | Heparin | None | LMWH | Heparin | LMWH |
| Secondary treatment | Warfarin | Warfarin | Warfarin | None | None | LMWH | None |
| Thrombosis outcome | Persistence of clot | Partial resolution of clot | Resolution of clot | Resolution of clot | Resolution of clot | Resolution of clot | Partial resolution of clot |
| Symptoms outcome | Resolved | Resolved | Resolved | Resolved | Resolved | Resolved | Resolved |
| ASP | Continued | Continued | Continued | Discontinued | Continued | Continued | Continued |
| Leukemia outcome | CR1 | CR1 | CR1 | CR1 | CR1 | CR1 | CR2 |
ASP indicates asparaginase; LMWH, low-molecular-weight heparin; CR1, first complete remission; and CR2, second complete remission.