Fraction (%) of CD38+ and CD38− 2H-labeled cells (f) in the clones of CLL patients involved in this study
| CLL patient no. . | 1st time point . | 2nd time point . | 3rd time point . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CD38+, f . | CD38−, f . | CD38+, f/CD38−, f . | CD38+, f . | CD38−, f . | CD38+, f/CD38−, f . | CD38+, f . | CD38−, f . | CD38+, f/CD38−, f . | |
| 189 | 30.0 | 17.0 | 1.8 | 31.0 | 26.0 | 1.2 | 24.0 | 29.0 | 0.8 |
| 280 | 7.5 | 8.5 | 0.9 | 15.6 | 12.0 | 1.3 | 16.9 | 12.6 | 1.3 |
| 321 | 19.5 | 14.1 | 1.4 | 26.5 | 19.2 | 1.4 | 20.4 | 22.5 | 0.9 |
| 332 | 2.4 | 1.5 | 1.6 | 3.2 | 2.1 | 1.5 | 16.0 | 14.0 | 1.1 |
| 355 | 2.1 | 1.9 | 1.1 | 8.9 | 7.3 | 1.2 | 26.6 | 21.3 | 1.2 |
| 452 | 16.0 | 2.7 | 5.9 | 25.0 | 8.4 | 3.0 | 9.1 | 7.3 | 1.2 |
| 546 | 28.0 | 4.7 | 5.9 | 34.4 | 10.7 | 3.2 | 10.7 | 9.5 | 1.1 |
| 569 | 24.0 | 8.7 | 2.8 | 40.7 | 16.3 | 2.5 | 21.7 | 21.0 | 1.0 |
| 606 | 46.2 | 22.1 | 2.8 | 73.3 | 8.9 | 8.2 | 4.8 | 5.1 | 0.9 |
| 625 | 1.8 | 1.5 | 1.2 | 9.7 | 6.4 | 1.5 | 13.4 | 10.0 | 1.3 |
| 822 | 26.5 | 5.3 | 5.0 | 44.0 | 11.0 | 4.0 | 20.8 | 13.3 | 1.6 |
| 875 | 3.6 | 1.8 | 2.0 | 6.6 | 5.3 | 1.2 | 4.7 | 5.0 | 0.9 |
| 931 | 8.7 | 3.3 | 2.6 | 18.4 | 12.1 | 1.5 | 8.1 | 7.5 | 1.1 |
| Average ± SE | 16.5 ± 3.9* | 7.3 ± 1.8* | 2.7 ± 0.5 | 25.9 ± 5.4† | 11.2 ± 1.7† | 2.4 ± 0.5 | 15.2 ± 2‡ | 13.7 ± 2.1‡ | 1.1 ± 0.1 |
| CLL patient no. . | 1st time point . | 2nd time point . | 3rd time point . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CD38+, f . | CD38−, f . | CD38+, f/CD38−, f . | CD38+, f . | CD38−, f . | CD38+, f/CD38−, f . | CD38+, f . | CD38−, f . | CD38+, f/CD38−, f . | |
| 189 | 30.0 | 17.0 | 1.8 | 31.0 | 26.0 | 1.2 | 24.0 | 29.0 | 0.8 |
| 280 | 7.5 | 8.5 | 0.9 | 15.6 | 12.0 | 1.3 | 16.9 | 12.6 | 1.3 |
| 321 | 19.5 | 14.1 | 1.4 | 26.5 | 19.2 | 1.4 | 20.4 | 22.5 | 0.9 |
| 332 | 2.4 | 1.5 | 1.6 | 3.2 | 2.1 | 1.5 | 16.0 | 14.0 | 1.1 |
| 355 | 2.1 | 1.9 | 1.1 | 8.9 | 7.3 | 1.2 | 26.6 | 21.3 | 1.2 |
| 452 | 16.0 | 2.7 | 5.9 | 25.0 | 8.4 | 3.0 | 9.1 | 7.3 | 1.2 |
| 546 | 28.0 | 4.7 | 5.9 | 34.4 | 10.7 | 3.2 | 10.7 | 9.5 | 1.1 |
| 569 | 24.0 | 8.7 | 2.8 | 40.7 | 16.3 | 2.5 | 21.7 | 21.0 | 1.0 |
| 606 | 46.2 | 22.1 | 2.8 | 73.3 | 8.9 | 8.2 | 4.8 | 5.1 | 0.9 |
| 625 | 1.8 | 1.5 | 1.2 | 9.7 | 6.4 | 1.5 | 13.4 | 10.0 | 1.3 |
| 822 | 26.5 | 5.3 | 5.0 | 44.0 | 11.0 | 4.0 | 20.8 | 13.3 | 1.6 |
| 875 | 3.6 | 1.8 | 2.0 | 6.6 | 5.3 | 1.2 | 4.7 | 5.0 | 0.9 |
| 931 | 8.7 | 3.3 | 2.6 | 18.4 | 12.1 | 1.5 | 8.1 | 7.5 | 1.1 |
| Average ± SE | 16.5 ± 3.9* | 7.3 ± 1.8* | 2.7 ± 0.5 | 25.9 ± 5.4† | 11.2 ± 1.7† | 2.4 ± 0.5 | 15.2 ± 2‡ | 13.7 ± 2.1‡ | 1.1 ± 0.1 |