Table 6 “Poor risk” gene signature:... | American Society of Hematology

Table 6

“Poor risk” gene signature: concordant in time-dependent AML evolution analysis, tMDS versus normal, and multiclass MDS progression analysis

Symbol	Cytogenetic band	Fold change*	Biologic process†
RPL23‡§‖	17q	17.0	11
RPS4X‡§‖	Xq13.1	16.9	11
RPS25‡	11q23.3	15.9	11
RPS19‡§‖	19q13.2	7.8	11
KLK3‖	19q13.41	5.9	2
TPP2‖	13q32-33	2.6	3

Symbol	Cytogenetic band	Fold change*	Biologic process†
RPL23‡§‖	17q	17.0	11
RPS4X‡§‖	Xq13.1	16.9	11
RPS25‡	11q23.3	15.9	11
RPS19‡§‖	19q13.2	7.8	11
KLK3‖	19q13.41	5.9	2
TPP2‖	13q32-33	2.6	3

Fold expression change in tMDS versus normal, 1% or 10% FDR.

Numbers correspond to the biologic process codes in Table 1.

Gene present in significant biologic process using hypergeometric analysis.

tMDS versus normal, 1% FDR.

tMDS versus sMDS, SAM significant at < 10%.