MDS versus normal: biologic processes engaged in by the differentially expressed genes
| Code . | Biologic process . | No. of genes* MDSvNl . | Percentage of genes† . | Percentage of genes in overrepresented biologic process‡ . |
|---|---|---|---|---|
| 1 | Cell adhesion | 27§ | 3 | 0 |
| 2 | Cytoskeleton + structural | 179 | 19 | 0 |
| 3 | Metabolism | 96 | 10 | 31 |
| 4 | Oxidative phosphorylation§ | 34§ | 3 | 100 |
| 5 | Apoptosis | 47 | 5 | 0 |
| 6 | Signaling, transport§ | 177§ | 18 | 13 |
| 7 | Proliferation | 28 | 3 | 14 |
| 8 | Cell cycle | 41 | 4 | 6 |
| 9 | Differentiation | 66 | 7 | 0 |
| 10 | Transcription§ | 182§ | 19 | 49 |
| 11 | Translational§ | 59§ | 6 | 29 |
| 12 | Protein ubiquitination | 11 | 1 | 0 |
| 13 | Other | 18 | 2 | 0 |
| Total | 965 | 100 | 64 |
| Code . | Biologic process . | No. of genes* MDSvNl . | Percentage of genes† . | Percentage of genes in overrepresented biologic process‡ . |
|---|---|---|---|---|
| 1 | Cell adhesion | 27§ | 3 | 0 |
| 2 | Cytoskeleton + structural | 179 | 19 | 0 |
| 3 | Metabolism | 96 | 10 | 31 |
| 4 | Oxidative phosphorylation§ | 34§ | 3 | 100 |
| 5 | Apoptosis | 47 | 5 | 0 |
| 6 | Signaling, transport§ | 177§ | 18 | 13 |
| 7 | Proliferation | 28 | 3 | 14 |
| 8 | Cell cycle | 41 | 4 | 6 |
| 9 | Differentiation | 66 | 7 | 0 |
| 10 | Transcription§ | 182§ | 19 | 49 |
| 11 | Translational§ | 59§ | 6 | 29 |
| 12 | Protein ubiquitination | 11 | 1 | 0 |
| 13 | Other | 18 | 2 | 0 |
| Total | 965 | 100 | 64 |
Significantly differentially expressed genes in our dataset (FDR = 10%) within biologic processes defined by Gene Ontology.
Percentage of genes within each process.
Percentage of genes within biologic processes, which were overrepresented and significant by hypergeometric analysis (P < .05).
Significant in GSEA, FDR ≤ 0.05.