Characteristics at diagnosis
| VH4-34 status and variant phenotype . | VH4-34+ . | VH4-34− . | P . | HCLv . | HCL . | P . |
|---|---|---|---|---|---|---|
| Median age at diagnosis (n) | 55.0 (14) | 45.6 (68) | .011 | 54.8 (20) | 45.7 (62) | .016 |
| Median, homology, % (n) | 99.4 (14) | 95.6 (71) | < .0001 | 97.6 (22) | 95.9 (63) | .12 |
| Median homology, %, classic HCL only (n) | 98.7 (6) | 95.6 (57) | .006 | |||
| Median homology, %, HCLv only (n) | 99.6 (8) | 95.7 (14) | .02 | |||
| White blood cell count, > 5 × 109/L (%) | 13/14 (93) | 23/57 (40) | .0006 | 15/18 (83) | 21/53 (40) | .002 |
| White blood cell count, > 5 × 109/L, classic HCL only (%) | 6/6 (100%) | 15/47 (32%) | .002 | |||
| White blood cell count > 5 × 109/L, VH4-34− only (%) | 8/10 (80%) | 15/47 (32%) | .01 | |||
| Median white blood cell count, ×109/L (n) | 9.0 (14) | 3.8 (57) | .002 | 11.3 (18) | 3.5 (53) | < .0001 |
| Median white blood cell count, ×109/L, classic HCL only (n) | 10.5 (6) | 2.9 (47) | .003 | |||
| Median white blood cell count, ×109/L, VH4-34− only (n) | 13.8 (10) | 2.9 (47) | .0003 | |||
| Median neutrophils, ×109/L (n) | 2.23 (12) | 0.82 (49) | .004 | 3.01 (14) | 0.77 (47) | < .0001 |
| Median hemoglobin, g/dL | 13.2 (13) | 11.6 (52) | .12 | 13.2 (17) | 11.4 (48) | .006 |
| Median platelets, ×109/L (n) | 105 (13) | 68 (54) | .014 | 135 (16) | 65 (51) | .0001 |
| VH4-34 status and variant phenotype . | VH4-34+ . | VH4-34− . | P . | HCLv . | HCL . | P . |
|---|---|---|---|---|---|---|
| Median age at diagnosis (n) | 55.0 (14) | 45.6 (68) | .011 | 54.8 (20) | 45.7 (62) | .016 |
| Median, homology, % (n) | 99.4 (14) | 95.6 (71) | < .0001 | 97.6 (22) | 95.9 (63) | .12 |
| Median homology, %, classic HCL only (n) | 98.7 (6) | 95.6 (57) | .006 | |||
| Median homology, %, HCLv only (n) | 99.6 (8) | 95.7 (14) | .02 | |||
| White blood cell count, > 5 × 109/L (%) | 13/14 (93) | 23/57 (40) | .0006 | 15/18 (83) | 21/53 (40) | .002 |
| White blood cell count, > 5 × 109/L, classic HCL only (%) | 6/6 (100%) | 15/47 (32%) | .002 | |||
| White blood cell count > 5 × 109/L, VH4-34− only (%) | 8/10 (80%) | 15/47 (32%) | .01 | |||
| Median white blood cell count, ×109/L (n) | 9.0 (14) | 3.8 (57) | .002 | 11.3 (18) | 3.5 (53) | < .0001 |
| Median white blood cell count, ×109/L, classic HCL only (n) | 10.5 (6) | 2.9 (47) | .003 | |||
| Median white blood cell count, ×109/L, VH4-34− only (n) | 13.8 (10) | 2.9 (47) | .0003 | |||
| Median neutrophils, ×109/L (n) | 2.23 (12) | 0.82 (49) | .004 | 3.01 (14) | 0.77 (47) | < .0001 |
| Median hemoglobin, g/dL | 13.2 (13) | 11.6 (52) | .12 | 13.2 (17) | 11.4 (48) | .006 |
| Median platelets, ×109/L (n) | 105 (13) | 68 (54) | .014 | 135 (16) | 65 (51) | .0001 |
HCL indicates classic hairy-cell leukemia; and HCLv, variant HCL.