Summary of protein expression and CRP-mediated events in WASp KO, WIP KOlow, and WIP KOhigh platelets
Protein expression/event . | WASp KO platelets . | WIP KOlow platelets . | WIP KOhigh platelets . |
---|---|---|---|
WASp expression | 0 | 0 | 0 |
WIP expression | 55 | 0 | 0 |
PLC-γ2 phosphorylation | 100 | 45-55 | 0-25 |
Calcium mobilization | 115-140 | 100 | 50-70 |
P-selectin expression | 110-120 | 100 | 60-80 |
αIIbβ3 activation | 100-110 | 55-100 | 25-45 |
Actin assembly | 110-125 | 95-125 | 35-75 |
Protein expression/event . | WASp KO platelets . | WIP KOlow platelets . | WIP KOhigh platelets . |
---|---|---|---|
WASp expression | 0 | 0 | 0 |
WIP expression | 55 | 0 | 0 |
PLC-γ2 phosphorylation | 100 | 45-55 | 0-25 |
Calcium mobilization | 115-140 | 100 | 50-70 |
P-selectin expression | 110-120 | 100 | 60-80 |
αIIbβ3 activation | 100-110 | 55-100 | 25-45 |
Actin assembly | 110-125 | 95-125 | 35-75 |
Values are percentages relative to protein expression and CRP-mediated events in WT platelets.