Diagnosis of PTLD
| Test . | Information gained . | Limitations . |
|---|---|---|
| EBV viral load | Elevated level supports diagnosis | High sensitivity; specificity varies with clinical scenario |
| Imaging | Enlarged lymph nodes or nodules support diagnosis | Differential causes for lymphadenopathy |
| Biopsy affected organ | Confirm EBV positivity by LMP1 immunostaining and EBERs; assess histology (high-grade monoclonal lymphoma vs polyclonal lymphoproliferation); immunophenotyping (CD20 expression); cytogenetics | Invasive procedure depending on organ involved |
| Test . | Information gained . | Limitations . |
|---|---|---|
| EBV viral load | Elevated level supports diagnosis | High sensitivity; specificity varies with clinical scenario |
| Imaging | Enlarged lymph nodes or nodules support diagnosis | Differential causes for lymphadenopathy |
| Biopsy affected organ | Confirm EBV positivity by LMP1 immunostaining and EBERs; assess histology (high-grade monoclonal lymphoma vs polyclonal lymphoproliferation); immunophenotyping (CD20 expression); cytogenetics | Invasive procedure depending on organ involved |