PTLD histologic classification (WHO classification 2008)
| Category . | Clonal status . | EBV status . | Oncogene/tumor suppressor gene changes . |
|---|---|---|---|
| ″Early″ lesions | |||
| Plasmacytic hyperplasia, infectious mononucleosis-like lesion | Polyclonal | Always EBV+ | None |
| Polymorphic PTLD | Monoclonal | Always EBV+ | None |
| Monomorphic | |||
| B-cell lymphomas (DLCL, Burkitt, plasma cell myeloma, Plasmacytoma-like lesions | Monoclonal | Frequently EBV+ | |
| T-cell lymphoma (peripheral T-cell lymphoma, hepatosplenic) | Rarely EBV+ | ||
| Classic Hodgkin lymphoma-like PTLD | Monoclonal | Frequently EBV+ | None |
| Category . | Clonal status . | EBV status . | Oncogene/tumor suppressor gene changes . |
|---|---|---|---|
| ″Early″ lesions | |||
| Plasmacytic hyperplasia, infectious mononucleosis-like lesion | Polyclonal | Always EBV+ | None |
| Polymorphic PTLD | Monoclonal | Always EBV+ | None |
| Monomorphic | |||
| B-cell lymphomas (DLCL, Burkitt, plasma cell myeloma, Plasmacytoma-like lesions | Monoclonal | Frequently EBV+ | |
| T-cell lymphoma (peripheral T-cell lymphoma, hepatosplenic) | Rarely EBV+ | ||
| Classic Hodgkin lymphoma-like PTLD | Monoclonal | Frequently EBV+ | None |
Data from Swerdlow et al.10