Significant factors predicting short PFS in multivariate analysis of clinical, phenotypic, and molecular prognostic features in the subset of 59 treated CLL patients
| Prognostic factor . | Risk of disease progression or death (PFS) . | ||
|---|---|---|---|
| Relative risk . | SE . | P . | |
| ZAP70+* | 3.85 | 0.59 | .021 |
| High TCL1 | 3.28 | 0.52 | .021 |
| Male sex | 2.14 | 0.42 | .045 |
| Prognostic factor . | Risk of disease progression or death (PFS) . | ||
|---|---|---|---|
| Relative risk . | SE . | P . | |
| ZAP70+* | 3.85 | 0.59 | .021 |
| High TCL1 | 3.28 | 0.52 | .021 |
| Male sex | 2.14 | 0.42 | .045 |
A 3-tier ZAP70 score (0 indicates absent; 1, weak; and 2, strong) as a better predictor than “positive” versus “negative” led to the elimination of male sex in this Cox hazard model; ZAP70 (0 vs 1 vs 2): RR = 2.58, SE = 0.28, P < .001 with the remaining factor, high TCL1: RR = 3.75, SE = 0.5, P = .009.