Table 5

Independent associations of tricuspid regurgitation velocity in multiple linear regression analysis models adjusted for age, sex, site, and chronic transfusion program.

Beta (95% CI)Standardized betaP
Analysis based on all participants with erythropoietin available*    
    Erythropoietin, IU/L, natural log 0.06 (0.02-0.11) 0.19 .003 
    Hemolytic component 0.05 (0.03-0.07) 0.27 < .001 
Analysis based on participants with value for hemoglobin F available    
    Hemoglobin F (%) 0.006 (0.001-0.01) 0.19 .023 
    Hemolytic component 0.06 (0.03-0.08) 0.35 < .001 
Beta (95% CI)Standardized betaP
Analysis based on all participants with erythropoietin available*    
    Erythropoietin, IU/L, natural log 0.06 (0.02-0.11) 0.19 .003 
    Hemolytic component 0.05 (0.03-0.07) 0.27 < .001 
Analysis based on participants with value for hemoglobin F available    
    Hemoglobin F (%) 0.006 (0.001-0.01) 0.19 .023 
    Hemolytic component 0.06 (0.03-0.08) 0.35 < .001 
*

n = 294; R-square = 0.19; variables entered into the analysis initially include erythropoietin, hemoglobin oxygen saturation, hemolytic component, and hydroxyurea therapy.

n = 142; R-square = 0.21; variables entered into the analysis initially include hemoglobin F percentage, hemoglobin oxygen saturation, hemolytic component, and hydroxyurea therapy. With hemoglobin F category in the model, P value for hemoglobin F = .002.

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