CI values for LY294002 and ara-C combinations at 50% inhibition levels in Meg-01 and primary pediatric AMkL cells
| Cell line/patients . | CI (50% inhibition) . | Relationship . | ||||
|---|---|---|---|---|---|---|
| 0.05 μM LY294002 . | 0.10 μM LY294002 . | 0.50 μM LY294002 . | 1.00 μM LY294002 . | 5.00 μM LY294002 . | ||
| Meg-01 | 0.88 | 0.73 | 0.69 | 0.70 | 0.87 | Synergistic |
| Patient 1 | 0.84 | 0.88 | 1.02 | Synergistic/additive | ||
| Patient 2 | 0.82 | 0.77 | 0.86 | Synergistic | ||
| Cell line/patients . | CI (50% inhibition) . | Relationship . | ||||
|---|---|---|---|---|---|---|
| 0.05 μM LY294002 . | 0.10 μM LY294002 . | 0.50 μM LY294002 . | 1.00 μM LY294002 . | 5.00 μM LY294002 . | ||
| Meg-01 | 0.88 | 0.73 | 0.69 | 0.70 | 0.87 | Synergistic |
| Patient 1 | 0.84 | 0.88 | 1.02 | Synergistic/additive | ||
| Patient 2 | 0.82 | 0.77 | 0.86 | Synergistic | ||
CI indicates combination index.