Clinical characteristics of patients with RARS-T compared with those of patients with RARS
| Variable . | Diagnosis . | P . | |
|---|---|---|---|
| RARS . | RARS-T . | ||
| No. of patients | 24 | 19 | |
| Median age, y (range) | 67 (33-84) | 59 (27-90) | NS |
| Median Hb level, g/dL (range) | 9.0 (6.4-12.1) | 10.1 (6.0-12.6) | .04 |
| Median WBC count, ×109/L (range) | 5.0 (2.9-7.8) | 6.8 (2.9-13.0) | < .001 |
| Median PLT count, ×109/L (range) | 271 (113-471) | 688 (475-1420) | < .001 |
| Median serum ferritin, ng/mL (range) | 669 (173-1800) | 443 (65-2010) | .04 |
| Median serum erythropoietin, mU/mL (range) | 89 (24-1000) | 37 (12-1000) | NS |
| Median percentage of ring sideroblasts (range) | 63 (23-94) | 51 (15-91) | NS |
| Abnormal megakaryocytes, proportion (%) | 1/24 (4) | 15/19 (79) | < .001 |
| Bone marrow fibrosis, proportion (%) | 0/24 (0) | 1/19 (5) | NS |
| Cytogenetic abnormalities, proportion (%) | 10/23 (43) | 2/19 (11) | .07 |
| JAK2/MPL mutations, proportion (%) | 0/24 (0) | 11/19 (58) | < .001 |
| Variable . | Diagnosis . | P . | |
|---|---|---|---|
| RARS . | RARS-T . | ||
| No. of patients | 24 | 19 | |
| Median age, y (range) | 67 (33-84) | 59 (27-90) | NS |
| Median Hb level, g/dL (range) | 9.0 (6.4-12.1) | 10.1 (6.0-12.6) | .04 |
| Median WBC count, ×109/L (range) | 5.0 (2.9-7.8) | 6.8 (2.9-13.0) | < .001 |
| Median PLT count, ×109/L (range) | 271 (113-471) | 688 (475-1420) | < .001 |
| Median serum ferritin, ng/mL (range) | 669 (173-1800) | 443 (65-2010) | .04 |
| Median serum erythropoietin, mU/mL (range) | 89 (24-1000) | 37 (12-1000) | NS |
| Median percentage of ring sideroblasts (range) | 63 (23-94) | 51 (15-91) | NS |
| Abnormal megakaryocytes, proportion (%) | 1/24 (4) | 15/19 (79) | < .001 |
| Bone marrow fibrosis, proportion (%) | 0/24 (0) | 1/19 (5) | NS |
| Cytogenetic abnormalities, proportion (%) | 10/23 (43) | 2/19 (11) | .07 |
| JAK2/MPL mutations, proportion (%) | 0/24 (0) | 11/19 (58) | < .001 |
RARS-T indicates refractory anemia with ringed sideroblasts associated with marked thrombocytosis; RARS, refractory anemia with ringed sideroblasts; NS, not significant; Hb, hemoglobin; WBC, white blood cell; and PLT, platelet.