ADA-SCID patients naive for therapy display significantly reduced growth
. | Age, y . | Percentile height, Z-score . | RANKL, pg/mL . | OPG, pg/mL . | RANKL/OPG, × 102 . |
---|---|---|---|---|---|
Patient no. 1 | 1 | −1.66 | 1.42 | 181.9 | 0.78 |
Patient no. 2 | 1.9 | −3.91 | 1.03 | 129.6 | 0.79 |
Patient no. 3 | 1.8 | −1.83 | 0 | 181.9 | 0 |
Patient no. 4 | 1.6 | −1.90 | 0 | 145.2 | 0 |
Patient no. 5 | 0.5 | −2.21 | 3.08 | 257.3 | 1.19 |
ND 1-5 years of age (n = 10), mean (SEM) | 11.49 (3) | 104.1 (7) | 13.4 (5) | ||
P | .005 | .003 | .011 |
. | Age, y . | Percentile height, Z-score . | RANKL, pg/mL . | OPG, pg/mL . | RANKL/OPG, × 102 . |
---|---|---|---|---|---|
Patient no. 1 | 1 | −1.66 | 1.42 | 181.9 | 0.78 |
Patient no. 2 | 1.9 | −3.91 | 1.03 | 129.6 | 0.79 |
Patient no. 3 | 1.8 | −1.83 | 0 | 181.9 | 0 |
Patient no. 4 | 1.6 | −1.90 | 0 | 145.2 | 0 |
Patient no. 5 | 0.5 | −2.21 | 3.08 | 257.3 | 1.19 |
ND 1-5 years of age (n = 10), mean (SEM) | 11.49 (3) | 104.1 (7) | 13.4 (5) | ||
P | .005 | .003 | .011 |
ND indicates normal donor.