Several types of systemic amyloidosis
| Amyloid type . | Precursor protein . | Clinical presentations . |
|---|---|---|
| AL | kappa or lambda light chains | Cardiac, renal, hepatic/GI, PNS, soft tissues |
| ATTR | Mutant transthyretin | Cardiac, PNS |
| Senile systemic | Wild-type transthyretin | Cardiac, pulmonary, PNS |
| AA* | Serum amyloid A | Renal |
| A Fib | Mutant fibrinogen A alpha | Renal, hepatic |
| AApo-A1 | Apolipoprotein A1 | Cardiac, renal, hepatic/GI, PNS, skin |
| Amyloid type . | Precursor protein . | Clinical presentations . |
|---|---|---|
| AL | kappa or lambda light chains | Cardiac, renal, hepatic/GI, PNS, soft tissues |
| ATTR | Mutant transthyretin | Cardiac, PNS |
| Senile systemic | Wild-type transthyretin | Cardiac, pulmonary, PNS |
| AA* | Serum amyloid A | Renal |
| A Fib | Mutant fibrinogen A alpha | Renal, hepatic |
| AApo-A1 | Apolipoprotein A1 | Cardiac, renal, hepatic/GI, PNS, skin |
GI indicates gastrointestinal; and PNS, peripheral nervous system.
AA is very rare in the developed world, but cases still occur in association with chronic infection, severe gout, ulcerative colitis, and metastatic renal cancer.