Table 5 Proposals for a minimal work-up... | American Society of Hematology

Table 5

Proposals for a minimal work-up in adults with a newly diagnosed ES

Proposals
Blood smear Serum protein electrophoresis and serum immunoelectrophoresis (immunofixation) Measurement of serum immunoglobulin concentrations Immunophenotyping of circulating B lymphocytes Antinuclear ± anti-dsDNA antibodies Anticardiolipid antibodies and lupus anticoagulant assay* HIV and HCV tests, HBV test† CT scan of the chest, abdomen, and pelvis Bone marrow biopsy‡

Proposals
Blood smear Serum protein electrophoresis and serum immunoelectrophoresis (immunofixation) Measurement of serum immunoglobulin concentrations Immunophenotyping of circulating B lymphocytes Antinuclear ± anti-dsDNA antibodies Anticardiolipid antibodies and lupus anticoagulant assay* HIV and HCV tests, HBV test† CT scan of the chest, abdomen, and pelvis Bone marrow biopsy‡

HCV indicates hepatitis C virus; and HBV, hepatitis B virus.

To be considered especially in patients with a history of venous and/or arterial thrombosis and/or in women with recurrent pregnancy loss.

To prevent viral reactivation in HBV carriers prior to corticosteroid therapy and especially if rituximab is considered.

To be considered in patients with features suggesting a lymphoproliferative disorder (monoclonal gammopathy).