Main characteristics of the 68 patients
| Characteristics . | Value . |
|---|---|
| Sex ratio (females/males) | 41 (60%)/27 |
| Mean age at ITP/AIHA onset | 55 ± 33 y |
| Mean (median and range) platelet level (×109/L) at ITP onset and/mean lowest level during follow-up | 31 (median 12.5: 2 to 100)/18 ± 15 |
| Mean Hb level (g/dL) at AIHA onset and/mean lowest level during follow-up | 7.6 ± 1.9/ 6.3 ± 1.2 |
| DAT pattern | |
| IgG | 43% |
| IgG + C3d | 53% |
| Negative | 4%* |
| No. of patients (%) who got a transfusion of packed red cell units for AIHA and/mean no. of units per patient | N = 32 (47%)/3.7 |
| No. of patients (%) with ITP-related bleeding symptoms | N = 44 (64%) |
| No. with a life-threatening hemorrhage | N = 3 (4.4%) |
| Characteristics . | Value . |
|---|---|
| Sex ratio (females/males) | 41 (60%)/27 |
| Mean age at ITP/AIHA onset | 55 ± 33 y |
| Mean (median and range) platelet level (×109/L) at ITP onset and/mean lowest level during follow-up | 31 (median 12.5: 2 to 100)/18 ± 15 |
| Mean Hb level (g/dL) at AIHA onset and/mean lowest level during follow-up | 7.6 ± 1.9/ 6.3 ± 1.2 |
| DAT pattern | |
| IgG | 43% |
| IgG + C3d | 53% |
| Negative | 4%* |
| No. of patients (%) who got a transfusion of packed red cell units for AIHA and/mean no. of units per patient | N = 32 (47%)/3.7 |
| No. of patients (%) with ITP-related bleeding symptoms | N = 44 (64%) |
| No. with a life-threatening hemorrhage | N = 3 (4.4%) |
DAT indicates direct antiglobulin test.
The 3 patients with a negative DAT had a simultaneous thrombocytopenia with a normal marrow and neither features of TTP on the smear nor any other cause of hemolytic anemia.