Cox proportional hazards model for association of FLC abnormalities with clinical outcome: unadjusted in all patients, adjusted for Rai stage in all patients, and unadjusted in patients with Rai stage 0
| . | All patients, unadjusted . | All patients, adjusted for Rai stage . | Rai stage 0 only . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| TTFT | |||||||||
| Normal FLC | 1.00 | Ref | — | 1.00 | Ref | — | 1.00 | Ref | — |
| Monoclonal FLC elevation | 5.57 | 3.29-9.44 | < .001 | 4.23 | 2.47-7.25 | < .001 | 7.49 | 1.77-31.6 | .0062 |
| Polyclonal FLC elevation | 2.12 | 1.08-4.17 | .029 | 1.52 | 1.06-4.12 | .25 | 2.73 | 0.46-16.7 | .27 |
| Ratio-only FLC abnormality | 2.75 | 1.51-5.03 | .0010 | 2.19 | 1.20-4.02 | .011 | 9.08 | 2.27-36.4 | .0018 |
| OS | |||||||||
| Normal FLC | 1.00 | Ref | — | 1.00 | Ref | — | 1.00 | Ref | — |
| Monoclonal FLC elevation | 5.38 | 2.23-12.98 | .001 | 4.89 | 2.00-11.92 | .001 | 10.50 | 2.49-44.26 | .0014 |
| Polyclonal FLC elevation | 5.37 | 2.19-13.17 | .001 | 4.76 | 1.90-11.89 | .001 | 5.00 | 1.00-24.92 | .050 |
| Ratio-only FLC abnormality | 0.38 | 0.05-3.03 | .36 | 0.34 | 0.04-2.67 | .30 | NA | ||
| . | All patients, unadjusted . | All patients, adjusted for Rai stage . | Rai stage 0 only . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| TTFT | |||||||||
| Normal FLC | 1.00 | Ref | — | 1.00 | Ref | — | 1.00 | Ref | — |
| Monoclonal FLC elevation | 5.57 | 3.29-9.44 | < .001 | 4.23 | 2.47-7.25 | < .001 | 7.49 | 1.77-31.6 | .0062 |
| Polyclonal FLC elevation | 2.12 | 1.08-4.17 | .029 | 1.52 | 1.06-4.12 | .25 | 2.73 | 0.46-16.7 | .27 |
| Ratio-only FLC abnormality | 2.75 | 1.51-5.03 | .0010 | 2.19 | 1.20-4.02 | .011 | 9.08 | 2.27-36.4 | .0018 |
| OS | |||||||||
| Normal FLC | 1.00 | Ref | — | 1.00 | Ref | — | 1.00 | Ref | — |
| Monoclonal FLC elevation | 5.38 | 2.23-12.98 | .001 | 4.89 | 2.00-11.92 | .001 | 10.50 | 2.49-44.26 | .0014 |
| Polyclonal FLC elevation | 5.37 | 2.19-13.17 | .001 | 4.76 | 1.90-11.89 | .001 | 5.00 | 1.00-24.92 | .050 |
| Ratio-only FLC abnormality | 0.38 | 0.05-3.03 | .36 | 0.34 | 0.04-2.67 | .30 | NA | ||
Ref indicates reference group; and NA, not applicable because of limited number of patients or events in the subgroup.