Summary of patient demographic and genetic results
| . | Total . | Translocation . | Deletion . |
|---|---|---|---|
| Total | |||
| Number | 97 | 33 | 64 |
| Median age, y (range) | 5.5 (1-76) | 16 (3-76) | 4 (1-35) |
| Median WBC, ×109/L (range) | 24.5 (1-400) | 40 (1-342) | 22 (1-400) |
| Additional X | 36/97 (37%) | 9/33 (27%) | 27/64* (42%) |
| iAMP21 | 11/97 (11%) | 0/33 (0%) | 11/64 (17%) |
| JAK2 mutation | 11/24 (46%) | 2/7 (29%) | 9/17 (53%) |
| CDKN2A deletions | 22/36† (61%) | 17/30† (57%) | 5/6‡ (83%) |
| PAX5 deletions | 7/13‡ (54%) | 3/7‡ (43%) | 4/6‡ (66%) |
| IKZF1 deletions | 8/13‡ (62%) | 5/7‡ (71%) | 3/6‡ (50%) |
| DS-ALL | |||
| Number | 41/97 | 6/33 | 35/64 |
| Median age, y (range) | 3.5 (1-16) | 16 (4-16) | 3 (1-16) |
| Median WBC, ×109/L (range) | 23.5 (2-400) | 22 (6-105) | 25 (2-400) |
| Additional X | 17/41 (42%) | 2/6 (33%) | 15/35* (43%) |
| iAMP21 | 0/41 (0%) | 0/6 (0%) | 0/35 (0%) |
| JAK2 mutation | 11/24 (46%) | 2/7 (29%) | 9/17 (53%) |
| CDKN2A deletions | 7/36† (19%) | 2/30§ (6%) | 5/6‡ (83%) |
| PAX5 deletions | 4/13‡ (31%) | 0/7‡ (0%) | 4/6‡ (66%) |
| IKZF1 deletions | 3/13‡ (23%) | 0/7‡ (0%) | 3/6‡ (50%) |
| Non-DS-ALL | |||
| Number | 56/97 | 27/33 | 29/64 |
| Median age, y (range) | 8 (1-76) | 17 (3-76) | 8 (1-15) |
| Median WBC, ×109/L (range) | 24 (1-342) | 40 (1-342) | 6 (2-205) |
| Additional X | 19/56 (34%) | 7/27 (26%) | 12/29* (41%) |
| iAMP21 | 11/56 (20%) | 0/27 (0%) | 11/29 (38%) |
| JAK2 mutation | ND | ND | ND |
| CDKN2A deletions | 15/36† (42%) | 15/30† (50%) | 0/6‡ (0%) |
| PAX5 deletions | 3/13‡ (23%) | 3/7‡ (43%) | 0/6‡ (0%) |
| IKZF1 deletions | 5/13‡ (39%) | 5/7‡ (71%) | 0/6‡ (0%) |
| . | Total . | Translocation . | Deletion . |
|---|---|---|---|
| Total | |||
| Number | 97 | 33 | 64 |
| Median age, y (range) | 5.5 (1-76) | 16 (3-76) | 4 (1-35) |
| Median WBC, ×109/L (range) | 24.5 (1-400) | 40 (1-342) | 22 (1-400) |
| Additional X | 36/97 (37%) | 9/33 (27%) | 27/64* (42%) |
| iAMP21 | 11/97 (11%) | 0/33 (0%) | 11/64 (17%) |
| JAK2 mutation | 11/24 (46%) | 2/7 (29%) | 9/17 (53%) |
| CDKN2A deletions | 22/36† (61%) | 17/30† (57%) | 5/6‡ (83%) |
| PAX5 deletions | 7/13‡ (54%) | 3/7‡ (43%) | 4/6‡ (66%) |
| IKZF1 deletions | 8/13‡ (62%) | 5/7‡ (71%) | 3/6‡ (50%) |
| DS-ALL | |||
| Number | 41/97 | 6/33 | 35/64 |
| Median age, y (range) | 3.5 (1-16) | 16 (4-16) | 3 (1-16) |
| Median WBC, ×109/L (range) | 23.5 (2-400) | 22 (6-105) | 25 (2-400) |
| Additional X | 17/41 (42%) | 2/6 (33%) | 15/35* (43%) |
| iAMP21 | 0/41 (0%) | 0/6 (0%) | 0/35 (0%) |
| JAK2 mutation | 11/24 (46%) | 2/7 (29%) | 9/17 (53%) |
| CDKN2A deletions | 7/36† (19%) | 2/30§ (6%) | 5/6‡ (83%) |
| PAX5 deletions | 4/13‡ (31%) | 0/7‡ (0%) | 4/6‡ (66%) |
| IKZF1 deletions | 3/13‡ (23%) | 0/7‡ (0%) | 3/6‡ (50%) |
| Non-DS-ALL | |||
| Number | 56/97 | 27/33 | 29/64 |
| Median age, y (range) | 8 (1-76) | 17 (3-76) | 8 (1-15) |
| Median WBC, ×109/L (range) | 24 (1-342) | 40 (1-342) | 6 (2-205) |
| Additional X | 19/56 (34%) | 7/27 (26%) | 12/29* (41%) |
| iAMP21 | 11/56 (20%) | 0/27 (0%) | 11/29 (38%) |
| JAK2 mutation | ND | ND | ND |
| CDKN2A deletions | 15/36† (42%) | 15/30† (50%) | 0/6‡ (0%) |
| PAX5 deletions | 3/13‡ (23%) | 3/7‡ (43%) | 0/6‡ (0%) |
| IKZF1 deletions | 5/13‡ (39%) | 5/7‡ (71%) | 0/6‡ (0%) |