Table 2 Current definition of complete... | American Society of Hematology

Table 2

Current definition of complete remission

	EBMT criteria,* Bladé et al¹⁵	IMWG uniform criteria,† Durie et al¹⁹
sCR	ND	CR plus normal FLC ratio Absence of clonal plasma cells by Immunochemistry or fluorescence
CR	Absence of M protein in serum and urine by IFX < 5% bone marrow plasma cells No increase of lytic bone lesions Disappearance of soft issue plasmacytomas	Same definition
VGPR	ND	Serum and urine M protein detectable by IFX but not on electrophoresis or 90% or greater reduction in serum M protein plus urine M-protein < 100 mg per 24 h

	EBMT criteria,* Bladé et al¹⁵	IMWG uniform criteria,† Durie et al¹⁹
sCR	ND	CR plus normal FLC ratio Absence of clonal plasma cells by Immunochemistry or fluorescence
CR	Absence of M protein in serum and urine by IFX < 5% bone marrow plasma cells No increase of lytic bone lesions Disappearance of soft issue plasmacytomas	Same definition
VGPR	ND	Serum and urine M protein detectable by IFX but not on electrophoresis or 90% or greater reduction in serum M protein plus urine M-protein < 100 mg per 24 h

sCR indicates stringent CR; ND, not defined; CR, complete response; FLC, free light chain; IFX, immunofixation; and VGPR, very good partial response.

Maintained at least 6 weeks.

Two consecutive assessments before any new therapy.