Table 4

Univariate analysis of prognostic factors for induction of CR, and the probabilities of OS, RFS, and EFS

VariableCR rate, %PSurvival probabilities at 5 years
OS, %PRFS, %PEFS, %P
Treatment arm         
    SD-DN 72.0 .014 34.6 .030 39.6 .432 28.4 .030 
    HD-DN 82.5  46.8  49.4  40.8  
Sex         
    Male 76.2 .589 39.4 .223 43.6 .252 33.2 .238 
    Female 78.5  42.3  46.1  36.2  
Age, y         
    ≤ 40 81.3 .117 47.1 .022 51.5 .097 42.0 .023 
    > 40 74.4  36.1  39.3  29.3  
Leukemia         
    De novo 78.1 .063 41.8 .009 45.0 .307 35.2 .056 
    Secondary 58.8  14.1‡  40.0‡  23.5‡  
Karnofsky performance score         
    ≥ 90 80.7 .001 42.1 .019 45.1 .401 36.4 .003 
    < 90 62.5  37.0  45.1  28.2  
Hemoglobin, g/dL         
    < 8.0 71.3 .017 31.4 .001 36.7 .091 26.1 .005 
    ≥ 8.0 81.6  47.3  49.8  40.6  
White blood cells, /μL         
    < 50 000 78.6 .245 42.8 .079 47.1 .077 37.1 .038 
    ≥ 50 000 72.7  33.6  35.7  26.0  
Uric acid, mg/dL*         
    < 7.0 77.2 .839 42.1 .078 47.6 .004 36.7 .041 
    ≥ 7.0 78.6  32.2  25.8  20.3  
LDH†         
    Normal 80.7 .551 44.6 .132 48.8 .183 39.4 .133 
    Elevated 77.1  39.8  44.4  34.2  
Cytogenetic risk group         
    Good 93.8 < .001 57.2 < .001 48.8 .001 45.9 < .001 
    Intermediate 74.9  41.8  47.5  35.6  
    Poor 64.9  14.0  21.6  14.0  
    Unknown 66.7  50.0  75.0  50.0  
VariableCR rate, %PSurvival probabilities at 5 years
OS, %PRFS, %PEFS, %P
Treatment arm         
    SD-DN 72.0 .014 34.6 .030 39.6 .432 28.4 .030 
    HD-DN 82.5  46.8  49.4  40.8  
Sex         
    Male 76.2 .589 39.4 .223 43.6 .252 33.2 .238 
    Female 78.5  42.3  46.1  36.2  
Age, y         
    ≤ 40 81.3 .117 47.1 .022 51.5 .097 42.0 .023 
    > 40 74.4  36.1  39.3  29.3  
Leukemia         
    De novo 78.1 .063 41.8 .009 45.0 .307 35.2 .056 
    Secondary 58.8  14.1‡  40.0‡  23.5‡  
Karnofsky performance score         
    ≥ 90 80.7 .001 42.1 .019 45.1 .401 36.4 .003 
    < 90 62.5  37.0  45.1  28.2  
Hemoglobin, g/dL         
    < 8.0 71.3 .017 31.4 .001 36.7 .091 26.1 .005 
    ≥ 8.0 81.6  47.3  49.8  40.6  
White blood cells, /μL         
    < 50 000 78.6 .245 42.8 .079 47.1 .077 37.1 .038 
    ≥ 50 000 72.7  33.6  35.7  26.0  
Uric acid, mg/dL*         
    < 7.0 77.2 .839 42.1 .078 47.6 .004 36.7 .041 
    ≥ 7.0 78.6  32.2  25.8  20.3  
LDH†         
    Normal 80.7 .551 44.6 .132 48.8 .183 39.4 .133 
    Elevated 77.1  39.8  44.4  34.2  
Cytogenetic risk group         
    Good 93.8 < .001 57.2 < .001 48.8 .001 45.9 < .001 
    Intermediate 74.9  41.8  47.5  35.6  
    Poor 64.9  14.0  21.6  14.0  
    Unknown 66.7  50.0  75.0  50.0  

LDH indicates lactate dehydrogenase.

*

Data on 8 patients were missing.

†

Data on 51 patients were missing.

‡

Survival probability at 4 years.

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