Table 1 Patient characteristics and... | American Society of Hematology

Table 1

Patient characteristics and treatment response

	Visit	Patient 1	Patient 2	Patient 3*	Patient 4	Patient 5	Patient 6
Age, y	—	22	40	38	31	50	54
Sex	—	Male	Male	Male	Female	Male	Male
Splenectomy (age, y)	—	No	Yes (21)	Yes (30)	Yes (7)	Yes (4)	Yes (5)
No. of transfusions in past year	—	0	4	1	1	1	0
No. of injections (wk)	—	24 (1-12)	21 (1-11)	4 (1-2)	16 (1-8)	24 (1-12)	16 (1-8)
Hemoglobin, g/dL	Baseline	8.8	10.7	8	6.1	7.8	6
	Peak†	9.4	11.8	—	7.7	8.7	7.6
	Week12‡	9.4	11.8	—	6.4	8.7	7.5
HbF, g/dL	Baseline	7	0.1	1.7	2.8	4.8	3.6
	Peak†	7.5	0.7	—	3.5	5.6	4.1
	Week12‡	7.1	0.7	—	3.4	5.6	3.6
Indirect bilirubin, μM	Baseline	25.7	104.3	47.9	89	33	20
	Nadir‡	27.4	83.8	—	48	18	8
	Week12	30.8	83.8	—	48	33	10
Serum lactate dehydrogenase, U/L	Baseline	893	596	543	458	192	258
	Nadir	660	541	—	260	149	204
	Week12	660	556	—	324	167	204
Platelet count, × 10⁹/L	Baseline	233	625	536	720	627	721
	Peak†	296	1038	—	1265	801	1301
	Week12‡	281	1038	—	1265	756	1301
Neutrophil count, × 10⁹/L	Baseline	5.57	5	5.4	5.6	5.1	11.3
	Nadir	2.82	2.2	—	5.2	2.1	4.5
	Week12	4.62	2.2	—	7.9	10.3	5.7
Absolute reticulocyte count, × 10⁹/L	Baseline	165	155	165	163	196	106
	Nadir‡	135	160	—	116	125	79
	Week12‡	135	160	—	116	145	79

	Visit	Patient 1	Patient 2	Patient 3*	Patient 4	Patient 5	Patient 6
Age, y	—	22	40	38	31	50	54
Sex	—	Male	Male	Male	Female	Male	Male
Splenectomy (age, y)	—	No	Yes (21)	Yes (30)	Yes (7)	Yes (4)	Yes (5)
No. of transfusions in past year	—	0	4	1	1	1	0
No. of injections (wk)	—	24 (1-12)	21 (1-11)	4 (1-2)	16 (1-8)	24 (1-12)	16 (1-8)
Hemoglobin, g/dL	Baseline	8.8	10.7	8	6.1	7.8	6
	Peak†	9.4	11.8	—	7.7	8.7	7.6
	Week12‡	9.4	11.8	—	6.4	8.7	7.5
HbF, g/dL	Baseline	7	0.1	1.7	2.8	4.8	3.6
	Peak†	7.5	0.7	—	3.5	5.6	4.1
	Week12‡	7.1	0.7	—	3.4	5.6	3.6
Indirect bilirubin, μM	Baseline	25.7	104.3	47.9	89	33	20
	Nadir‡	27.4	83.8	—	48	18	8
	Week12	30.8	83.8	—	48	33	10
Serum lactate dehydrogenase, U/L	Baseline	893	596	543	458	192	258
	Nadir	660	541	—	260	149	204
	Week12	660	556	—	324	167	204
Platelet count, × 10⁹/L	Baseline	233	625	536	720	627	721
	Peak†	296	1038	—	1265	801	1301
	Week12‡	281	1038	—	1265	756	1301
Neutrophil count, × 10⁹/L	Baseline	5.57	5	5.4	5.6	5.1	11.3
	Nadir	2.82	2.2	—	5.2	2.1	4.5
	Week12	4.62	2.2	—	7.9	10.3	5.7
Absolute reticulocyte count, × 10⁹/L	Baseline	165	155	165	163	196	106
	Nadir‡	135	160	—	116	125	79
	Week12‡	135	160	—	116	145	79

Additional patient characteristics are given in supplemental Table 1; additional laboratory values are given in supplemental Table 2.

— indicates not applicable.

Patient 3 withdrew at week 2 because of fatigue requiring transfusion.

P < .01.

P < .05.