Characteristics of patients analyzed for TP53 mutations within the CLL2H trial
| Hierarchical categorization of genomic aberrations . | Total (n = 99) . | WT TP53 (n = 62) . | Mutated TP53 (n = 37) . | P . | |||
|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | ||
| Trisomy 12 | 7 | 7 | 6 | 10 | 1 | 3 | .25 |
| 11q− | 20 | 20 | 19 | 31 | 1 | 3 | < .001 |
| 13q− sole | 19 | 19 | 13 | 21 | 6 | 16 | .6 |
| 17p− | 32 | 32 | 7 | 11 | 25 | 68 | < .001 |
| Other | 3 | 3 | 2 | 3 | 1 | 3 | 1 |
| Normal | 18 | 18 | 15 | 24 | 3 | 8 | .06 |
| VH mutation status | |||||||
| Mutated | 22 | 22 | 12 | 19 | 10 | 27 | |
| Unmutated | 70 | 71 | 44 | 71 | 26 | 70 | .6 |
| NA | 7 | 7 | 6 | 10 | 1 | 3 | |
| Response | |||||||
| CR | 4 | 4 | 3 | 5 | 1 | 3 | 1 |
| PR | 30 | 30 | 22 | 35 | 8 | 22 | .25 |
| SD | 37 | 37 | 24 | 39 | 13 | 35 | 1 |
| PD | 24 | 24 | 12 | 19 | 12 | 32 | .14 |
| NA | 4 | 4 | 1 | 2 | 3 | 8 | |
| Hierarchical categorization of genomic aberrations . | Total (n = 99) . | WT TP53 (n = 62) . | Mutated TP53 (n = 37) . | P . | |||
|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | ||
| Trisomy 12 | 7 | 7 | 6 | 10 | 1 | 3 | .25 |
| 11q− | 20 | 20 | 19 | 31 | 1 | 3 | < .001 |
| 13q− sole | 19 | 19 | 13 | 21 | 6 | 16 | .6 |
| 17p− | 32 | 32 | 7 | 11 | 25 | 68 | < .001 |
| Other | 3 | 3 | 2 | 3 | 1 | 3 | 1 |
| Normal | 18 | 18 | 15 | 24 | 3 | 8 | .06 |
| VH mutation status | |||||||
| Mutated | 22 | 22 | 12 | 19 | 10 | 27 | |
| Unmutated | 70 | 71 | 44 | 71 | 26 | 70 | .6 |
| NA | 7 | 7 | 6 | 10 | 1 | 3 | |
| Response | |||||||
| CR | 4 | 4 | 3 | 5 | 1 | 3 | 1 |
| PR | 30 | 30 | 22 | 35 | 8 | 22 | .25 |
| SD | 37 | 37 | 24 | 39 | 13 | 35 | 1 |
| PD | 24 | 24 | 12 | 19 | 12 | 32 | .14 |
| NA | 4 | 4 | 1 | 2 | 3 | 8 | |
WT indicates wild type; CR, complete remission; PR, partial remission; SD, stable disease; PD, progressive disease; and NA, not available.