Differentially regulated groups of genes in CBE-treated cells
| Gene ontology group . | Trend . | Up-regulated (total 133)* . | Down-regulated (total 212)* . |
|---|---|---|---|
| Proteolysis (GO:0006508) other than ubiquitin cycle | ▴ | CTSZ, MMP2, SHFM1, CLPP, HTRA1, C1orf57 | PSMA1, BLMH |
| Ubiquitin cycle (GO:0006512) | ▾ | USP4, TSC1, FBXL5, NEDD8 | FBXL15, ANAPC7, FBXO42, BRAP, RNF34, FBXW7, USP1, APPBP1, CDC23, SKP2, USP16, SENP6, SPOP |
| Inflammatory response (GO:0006954) | ▴ | CCL2, IL8RA, TGM2, ANXA1, FN1 | ABCF1 |
| Lipid homeostasis (GO:0055088) | ▴ | NPC2, PLSCR3, SCP2 | |
| Phosphoinositide biosynthetic process (GO :0046489) | ▾ | PIGS, IMPA1, PIGT | |
| Lysosome compartment (GO:0005764) | ▴ | ACP5, NPC2, AGA, CTSZ, USP4, GABARAP, TMEM55A | LAMP2 |
| Actin cytoskeleton (GO:0015629) | ▴ | GSN, CLIC4, ACTR3, TSC1, GABARAP, MRCL3, VASP, MYL2, ACTR2, DYNLL2 | TNNC2 |
| Transcription factor activity (GO:0003700) | ▾ | FOSL2, DDIT3, ELF2, HNRPAB | HSF1, HOXB9, KLF9, RFX5, FBXW7, TP53, SUPT6H, KLF4, RB1, TCFL5, JUND, CREB3L1, ZNF449, ZFP36L1 |
| Gene ontology group . | Trend . | Up-regulated (total 133)* . | Down-regulated (total 212)* . |
|---|---|---|---|
| Proteolysis (GO:0006508) other than ubiquitin cycle | ▴ | CTSZ, MMP2, SHFM1, CLPP, HTRA1, C1orf57 | PSMA1, BLMH |
| Ubiquitin cycle (GO:0006512) | ▾ | USP4, TSC1, FBXL5, NEDD8 | FBXL15, ANAPC7, FBXO42, BRAP, RNF34, FBXW7, USP1, APPBP1, CDC23, SKP2, USP16, SENP6, SPOP |
| Inflammatory response (GO:0006954) | ▴ | CCL2, IL8RA, TGM2, ANXA1, FN1 | ABCF1 |
| Lipid homeostasis (GO:0055088) | ▴ | NPC2, PLSCR3, SCP2 | |
| Phosphoinositide biosynthetic process (GO :0046489) | ▾ | PIGS, IMPA1, PIGT | |
| Lysosome compartment (GO:0005764) | ▴ | ACP5, NPC2, AGA, CTSZ, USP4, GABARAP, TMEM55A | LAMP2 |
| Actin cytoskeleton (GO:0015629) | ▴ | GSN, CLIC4, ACTR3, TSC1, GABARAP, MRCL3, VASP, MYL2, ACTR2, DYNLL2 | TNNC2 |
| Transcription factor activity (GO:0003700) | ▾ | FOSL2, DDIT3, ELF2, HNRPAB | HSF1, HOXB9, KLF9, RFX5, FBXW7, TP53, SUPT6H, KLF4, RB1, TCFL5, JUND, CREB3L1, ZNF449, ZFP36L1 |
This table lists relevant groups of genes that are significantly and consistently differentially regulated.
Genes regulated significantly (log2 ratio > 0.25 or < −0.25, and P < .05) and consistently (at least 2 out of 3 cell types).