Table 3

Univariate analysis of common prognostic markers and response to PCLI as predictors of overall survival

Prognostic variableProportional hazard ratio95% CIP
Age > 65 y 1.15 0.73-1.67 .60 
Albumin < 3.5 g/dL 1.23 0.84-1.78 .28 
β2M > 3.5 mg/dL 1.47 1.01-2.14 .042* 
Creatinine > 1.4 1.51 1.02-2.22 .042* 
Hemoglobin < 10 g/dL 1.20 0.82-1.74 .34 
Serum M-spike response < 50% 1.64 1.13-2.38 .009* 
PCLI response < 60% 1.56 1.08-2.25 .019* 
Initial PCLI    
    ≥ 3% 2.54 1.50-4.08 < .001* 
    ≥ 1% 1.42 0.96-2.12 .08 
Prognostic variableProportional hazard ratio95% CIP
Age > 65 y 1.15 0.73-1.67 .60 
Albumin < 3.5 g/dL 1.23 0.84-1.78 .28 
β2M > 3.5 mg/dL 1.47 1.01-2.14 .042* 
Creatinine > 1.4 1.51 1.02-2.22 .042* 
Hemoglobin < 10 g/dL 1.20 0.82-1.74 .34 
Serum M-spike response < 50% 1.64 1.13-2.38 .009* 
PCLI response < 60% 1.56 1.08-2.25 .019* 
Initial PCLI    
    ≥ 3% 2.54 1.50-4.08 < .001* 
    ≥ 1% 1.42 0.96-2.12 .08 

β2M indicates β2-microglobulin; CI, confidence interval; and PCLI, plasma cell labeling index.

*

Statistically significant.

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