Correlation of TET2 mutation with other gene alterations
| Mutation . | Total (n = 486) . | TET2-mutated (n = 64) . | TET2-wild (n = 422) . | P . |
|---|---|---|---|---|
| NPM1 | 102 (21.0) | 20 (31.3) | 82 (19.4) | .047 |
| FLT3-ITD | 113 (23.3) | 14 (21.9) | 99 (23.5) | .847 |
| NPM1+/FLT3-ITD− | 50 (10.3) | 10 (15.6) | 40 (9.5) | .181 |
| CEBPAdouble | 45 (9.3) | 8 (12.5) | 37 (8.8) | .353 |
| WT1 | 32 (6.6) | 2 (3.1) | 30 (7.1) | .291 |
| RUNX1 | 58 (11.9) | 8 (12.5) | 50 (11.8) | .837 |
| IDH | 80 (16.5) | 1 (1.6) | 79 (18.7) | < .001 |
| FLT3-TKD | 40 (8.2) | 4 (6.3) | 36 (8.5) | .806 |
| MLL-PTD | 25 (5.1) | 2 (3.1) | 23 (5.5) | .759 |
| KIT | 14 (2.9) | 0 | 14 (3.3) | .233 |
| NRAS | 56 (11.5) | 6 (9.4) | 50 (11.8) | .678 |
| KRAS | 17 (3.5) | 1 (1.6) | 16 (3.8) | .712 |
| ASXL1 | 53 (10.9) | 15 (23.4) | 38 (9) | .002 |
| Mutation . | Total (n = 486) . | TET2-mutated (n = 64) . | TET2-wild (n = 422) . | P . |
|---|---|---|---|---|
| NPM1 | 102 (21.0) | 20 (31.3) | 82 (19.4) | .047 |
| FLT3-ITD | 113 (23.3) | 14 (21.9) | 99 (23.5) | .847 |
| NPM1+/FLT3-ITD− | 50 (10.3) | 10 (15.6) | 40 (9.5) | .181 |
| CEBPAdouble | 45 (9.3) | 8 (12.5) | 37 (8.8) | .353 |
| WT1 | 32 (6.6) | 2 (3.1) | 30 (7.1) | .291 |
| RUNX1 | 58 (11.9) | 8 (12.5) | 50 (11.8) | .837 |
| IDH | 80 (16.5) | 1 (1.6) | 79 (18.7) | < .001 |
| FLT3-TKD | 40 (8.2) | 4 (6.3) | 36 (8.5) | .806 |
| MLL-PTD | 25 (5.1) | 2 (3.1) | 23 (5.5) | .759 |
| KIT | 14 (2.9) | 0 | 14 (3.3) | .233 |
| NRAS | 56 (11.5) | 6 (9.4) | 50 (11.8) | .678 |
| KRAS | 17 (3.5) | 1 (1.6) | 16 (3.8) | .712 |
| ASXL1 | 53 (10.9) | 15 (23.4) | 38 (9) | .002 |
Values are no. (%) of patients.