Examples of HLA-A, -B, and -DRB1 mismatches and mismatch direction
HLA matched | |||||
Patient | A2 | A68 | B8 | B65 | DRB1*0102 DRB1*0301 |
CBU | A2 | A68 | B8 | B65 | DRB1*0102 DRB1*0301 |
1 HLA mismatch, bidirectional | |||||
Patient | A1 | A2 | B8 | B50 | DRB1*0301 DRB1*0701 |
CBU | A1 | A2 | B8 | B45 | DRB1*0301 DRB1*0701 |
2 HLA mismatches, both bidirectional | |||||
Patient | A2 | A68 | B61 | B57 | DRB1*0411 DRB1*1103 |
CBU | A2 | A68 | B61 | B70 | DRB1*0411 DRB1*0101 |
1 HLA mismatch, GVH-O | |||||
Patient | A2 | A30 | B7 | B58 | DRB1*1102 DRB1*1503 |
CBU | A2 | A– | B7 | B58 | DRB1*1102 DRB1*1503 |
2 HLA mismatches, GVH-O | |||||
Patient | A3 | A68 | B49 | B53 | DRB1*0804 DRB1*1303 |
CBU | A– | A68 | B49 | B53 | DRB1*0804 DRB1*—- |
1 HLA mismatch, R-O | |||||
Patient | A2 | A– | B7 | B44 | DRB1*0401 DRB1*1501 |
CBU | A2 | A3 | B7 | B44 | DRB1*0401 DRB1*1501 |
2 HLA mismatches, R-O | |||||
Patient | A24 | A29 | B44 | B– | DRB1*—- DRB1*1302 |
CBU | A24 | A29 | B44 | B57 | DRB1*0701 DRB1*1302 |
2 HLA mismatches, 1 bidirectional & 1 GVH | |||||
Patient | A2 | A11 | B7 | B35 | DRB1*0407 DRB1*1501 |
CBU | A2 | A– | B7 | B35 | DRB1*1201 DRB1*1501 |
2 HLA mismatches, 1 bidirectional & 1 rejection | |||||
Patient | A– | A33 | B45 | B63 | DRB1*0102 DRB1*0301 |
CBU | A24 | A33 | B45 | B58 | DRB1*0102 DRB1*0301 |
2 HLA mismatches, 1 GVH & 1 rejection | |||||
Patient | A– | A2 | B7 | B37 | DRB1*0301 DRB1*1501 |
CBU | A1 | A2 | B7 | B37 | DRB1*—- DRB1*1501 |
HLA matched | |||||
Patient | A2 | A68 | B8 | B65 | DRB1*0102 DRB1*0301 |
CBU | A2 | A68 | B8 | B65 | DRB1*0102 DRB1*0301 |
1 HLA mismatch, bidirectional | |||||
Patient | A1 | A2 | B8 | B50 | DRB1*0301 DRB1*0701 |
CBU | A1 | A2 | B8 | B45 | DRB1*0301 DRB1*0701 |
2 HLA mismatches, both bidirectional | |||||
Patient | A2 | A68 | B61 | B57 | DRB1*0411 DRB1*1103 |
CBU | A2 | A68 | B61 | B70 | DRB1*0411 DRB1*0101 |
1 HLA mismatch, GVH-O | |||||
Patient | A2 | A30 | B7 | B58 | DRB1*1102 DRB1*1503 |
CBU | A2 | A– | B7 | B58 | DRB1*1102 DRB1*1503 |
2 HLA mismatches, GVH-O | |||||
Patient | A3 | A68 | B49 | B53 | DRB1*0804 DRB1*1303 |
CBU | A– | A68 | B49 | B53 | DRB1*0804 DRB1*—- |
1 HLA mismatch, R-O | |||||
Patient | A2 | A– | B7 | B44 | DRB1*0401 DRB1*1501 |
CBU | A2 | A3 | B7 | B44 | DRB1*0401 DRB1*1501 |
2 HLA mismatches, R-O | |||||
Patient | A24 | A29 | B44 | B– | DRB1*—- DRB1*1302 |
CBU | A24 | A29 | B44 | B57 | DRB1*0701 DRB1*1302 |
2 HLA mismatches, 1 bidirectional & 1 GVH | |||||
Patient | A2 | A11 | B7 | B35 | DRB1*0407 DRB1*1501 |
CBU | A2 | A– | B7 | B35 | DRB1*1201 DRB1*1501 |
2 HLA mismatches, 1 bidirectional & 1 rejection | |||||
Patient | A– | A33 | B45 | B63 | DRB1*0102 DRB1*0301 |
CBU | A24 | A33 | B45 | B58 | DRB1*0102 DRB1*0301 |
2 HLA mismatches, 1 GVH & 1 rejection | |||||
Patient | A– | A2 | B7 | B37 | DRB1*0301 DRB1*1501 |
CBU | A1 | A2 | B7 | B37 | DRB1*—- DRB1*1501 |
Matched antigens are shown in regular type and mismatched antigens are in bold. Bidirectional means that mismatch was in both the GVH and rejection directions.
CBU indicate cord blood unit; GVH, graft-versus-host; GVH-O, graft-versus-host only; R-O, rejection only; and HLA, human leukocyte antigen.