Spleen progenitors (colonies/104 cells)
| . | WT (n = 5) . | Het (n = 4) . | KO (n = 5) . |
|---|---|---|---|
| BFU-E | 7.2 ± 1.89 | 3.5 ± 0.88 | 0 ± 0* |
| CFU-E | 7.4 ± 2.87 | 5.0 ± 1.00 | 0.2 ± 0.14* |
| CFU-GM | 22.6 ± 6.32 | 11.0 ± 2.25 | 0.2 ± 0.14* |
| . | WT (n = 5) . | Het (n = 4) . | KO (n = 5) . |
|---|---|---|---|
| BFU-E | 7.2 ± 1.89 | 3.5 ± 0.88 | 0 ± 0* |
| CFU-E | 7.4 ± 2.87 | 5.0 ± 1.00 | 0.2 ± 0.14* |
| CFU-GM | 22.6 ± 6.32 | 11.0 ± 2.25 | 0.2 ± 0.14* |
A total of 40 000 splenocytes from postnatal day 13 and 15 mice were plated in duplicate in methylcellulose medium and the number of colonies determined 12 days after plating. Data represent the mean ± SEM.
P < .05 by one-way analysis of variance with Tukey HSD post hoc test.