Table 1

Genes differentially methylated between MDS and de novo AML

Gene symbolDescription
ACSL1 Acyl-CoA synthetase long-chain family member 1 
AIM2 Absent in melanoma 2 
AOC3 Amine oxidase, copper containing 3 precursor 
ASGR2 Asialoglycoprotein receptor 2 
BRCA2 Breast cancer 2, early onset 
CACNA1I Calcium channel, voltage-dependent, T type, 
CDR2 Cerebellar degeneration-related protein 2 
EID2 CREBBP/EP300 inhibitor 2 
ELOVL6 Elongation of very long chain fatty acids-like 
ESPL1 Extra spindle poles like 1 
ESPNL Espin-like 
EXOC7 Exocyst complex component 7 
FHL2 Four and a half LIM domains 2 
FOXP4 Forkhead box P4 
GGNBP2 Gametogenetin-binding protein 2 (Laryngeal carcinoma- related protein 1) 
GHRL Ghrelin precursor 
GNAZ Guanine nucleotide binding protein, α z 
GNG4 Guanine nucleotide binding protein (G protein) 
HOXB5 Homeobox B5 
HYAL3 Hyaluronoglucosaminidase 3 
IFNGR2 Interferon γ receptor 2 precursor 
ITGAE Integrin, α E precursor 
KRTCAP2 Keratinocyte associated protein 2 
LCE3E Late-cornified envelope 3E 
LRFN4 Leucine-rich repeat and fibronectin type III 
LRP6 Low-density lipoprotein receptor-related protein 
MED25 ARC/mediator transcriptional coactivator 
MICALL2 MICAL-like 2 isoform 1 
MTMR11 Myotubularin-related protein 11 (Cisplatin resistance-associated protein) 
NAT6 N-acetyltransferase 6 
NOTCH4 Notch4 preproprotein 
NPEPL1 Aminopeptidase-like 1 
NRTN Neurturin preproprotein 
PEX11A Peroxisomal biogenesis factor 11A 
PHLDB1 Pleckstrin homology-like domain, family B 
PILRA Paired immunoglobulin-like type 2 receptor α 
PPARD Peroxisome proliferative activated receptor-δ isoform 
PRF1 Perforin 1 precursor 
PTPRS Protein tyrosine phosphatase, receptor type 
PYDC1 Pyrin domain containing 1 
RAG1AP1 Recombination activating gene 1 activating 
RHOT1 Ras homolog gene family, member T1 
RNH1 Ribonuclease/angiogenin inhibitor 
SERPINB13 Serine (or cysteine) proteinase inhibitor, clade 
SIRT1 Sirtuin 1 
SLC20A2 Solute carrier family 20, member 2 
SLC26A9 Solute carrier family 26, member 9 isoform a 
SLC39A13 Solute carrier family 39 (zinc transporter) 
SPATS1 Spermatogenesis-associated serine-rich protein 1 
SPRN Shadow of prion protein 
ST3GAL3 Sialyltransferase 6 
SULT1A1 Sulfotransferase family, cytosolic, 1A 
TGFA Transforming growth factor, α 
TIMP3 Tissue inhibitor of metalloproteinase 3 
TMEM33 Transmembrane protein 33 
TMEM41B Transmembrane protein 41B 
TMEM52 Transmembrane protein 52 
TRIM46 Tripartite motif-containing 46 
TRPV3 Transient receptor potential cation channel 
TSEN2 tRNA splicing endonuclease 2 homolog 
ZNF212 Zinc finger protein 212 
ZNF606 Zic finger protein 606 
ZNF74 Zinc finger protein 74 
Gene symbolDescription
ACSL1 Acyl-CoA synthetase long-chain family member 1 
AIM2 Absent in melanoma 2 
AOC3 Amine oxidase, copper containing 3 precursor 
ASGR2 Asialoglycoprotein receptor 2 
BRCA2 Breast cancer 2, early onset 
CACNA1I Calcium channel, voltage-dependent, T type, 
CDR2 Cerebellar degeneration-related protein 2 
EID2 CREBBP/EP300 inhibitor 2 
ELOVL6 Elongation of very long chain fatty acids-like 
ESPL1 Extra spindle poles like 1 
ESPNL Espin-like 
EXOC7 Exocyst complex component 7 
FHL2 Four and a half LIM domains 2 
FOXP4 Forkhead box P4 
GGNBP2 Gametogenetin-binding protein 2 (Laryngeal carcinoma- related protein 1) 
GHRL Ghrelin precursor 
GNAZ Guanine nucleotide binding protein, α z 
GNG4 Guanine nucleotide binding protein (G protein) 
HOXB5 Homeobox B5 
HYAL3 Hyaluronoglucosaminidase 3 
IFNGR2 Interferon γ receptor 2 precursor 
ITGAE Integrin, α E precursor 
KRTCAP2 Keratinocyte associated protein 2 
LCE3E Late-cornified envelope 3E 
LRFN4 Leucine-rich repeat and fibronectin type III 
LRP6 Low-density lipoprotein receptor-related protein 
MED25 ARC/mediator transcriptional coactivator 
MICALL2 MICAL-like 2 isoform 1 
MTMR11 Myotubularin-related protein 11 (Cisplatin resistance-associated protein) 
NAT6 N-acetyltransferase 6 
NOTCH4 Notch4 preproprotein 
NPEPL1 Aminopeptidase-like 1 
NRTN Neurturin preproprotein 
PEX11A Peroxisomal biogenesis factor 11A 
PHLDB1 Pleckstrin homology-like domain, family B 
PILRA Paired immunoglobulin-like type 2 receptor α 
PPARD Peroxisome proliferative activated receptor-δ isoform 
PRF1 Perforin 1 precursor 
PTPRS Protein tyrosine phosphatase, receptor type 
PYDC1 Pyrin domain containing 1 
RAG1AP1 Recombination activating gene 1 activating 
RHOT1 Ras homolog gene family, member T1 
RNH1 Ribonuclease/angiogenin inhibitor 
SERPINB13 Serine (or cysteine) proteinase inhibitor, clade 
SIRT1 Sirtuin 1 
SLC20A2 Solute carrier family 20, member 2 
SLC26A9 Solute carrier family 26, member 9 isoform a 
SLC39A13 Solute carrier family 39 (zinc transporter) 
SPATS1 Spermatogenesis-associated serine-rich protein 1 
SPRN Shadow of prion protein 
ST3GAL3 Sialyltransferase 6 
SULT1A1 Sulfotransferase family, cytosolic, 1A 
TGFA Transforming growth factor, α 
TIMP3 Tissue inhibitor of metalloproteinase 3 
TMEM33 Transmembrane protein 33 
TMEM41B Transmembrane protein 41B 
TMEM52 Transmembrane protein 52 
TRIM46 Tripartite motif-containing 46 
TRPV3 Transient receptor potential cation channel 
TSEN2 tRNA splicing endonuclease 2 homolog 
ZNF212 Zinc finger protein 212 
ZNF606 Zic finger protein 606 
ZNF74 Zinc finger protein 74 

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