Genes regulated following CA-IKK2 induction in Ramos cells
| Gene ID . | Gene name . | Fold change . |
|---|---|---|
| Cell adhesion | ||
| IL32 | Interleukin 32 | 18.4 |
| CCL5 | Chemokine (C-C motif) ligand 5 | 17.8 |
| ICAM1 | Intercellular adhesion molecule 1 (CD54) | 13.5 |
| FBLN5 | Fibulin 5 | 6.3 |
| ITGB2 | Integrin, beta 2 (CD18) | 5.7 |
| ADAM8 | ADAM metallopeptidase domain 8 | 5.2 |
| ITGAM | Integrin, alpha M (CD11b) | 3.4 |
| FCGBP | Fc fragment of IgG binding protein | 3.3 |
| CD58 | CD58 molecule | 3.0 |
| Apoptosis (proapoptotic) | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 29.7 |
| BTG1 | B-cell translocation gene 1 | 4.5 |
| PLAGL1 | Pleiomorphic adenoma gene-like 1 | 4.1 |
| IFIH1 | Interferon induced with helicase C domain 1 | 3.5 |
| BID | BH3 interacting domain death agonist | 2.3 |
| RUNX3 | Runt-related transcription factor 3 | 2.0 |
| ID3 | Inhibitor of DNA binding 3 | 0.5 |
| Apoptosis (antiapoptotic) | ||
| BCL2A1 | BCL2-related protein A1 | 84.2 |
| SGK1 | Serum/glucocorticoid regulated kinase 1 | 30.9 |
| TNFRSF9 | Tumor necrosis factor receptor superfamily, member 9 | 23.6 |
| TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | 17.1 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 6.7 |
| IL1B | Interleukin 1 beta | 6.3 |
| NUP62 | Nucleoporin 62 kDa | 5.1 |
| ATF5 | Activating transcription factor 5 | 3.7 |
| TRAF1 | TNF receptor-associated factor 1 | 3.0 |
| PIM1 | Pim-1 oncogene | 2.9 |
| IL2RA | Interleukin 2 receptor alpha | 2.7 |
| BIR3 | baculoviral IAP repeat-containing 3 | 2.6 |
| IER3 | Immediate early response 3 | 2.5 |
| BCL2 | B-cell CLL/lymphoma 2 | 2.5 |
| BCL3 | B-cell CLL/lymphoma 3 | 2.5 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2.4 |
| NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2.4 |
| NEK6 | NIMA (never in mitosis gene a)–related kinase 6 | 2.3 |
| BCL2L1 | BCL2-like 1 | 2.1 |
| Cell cycle (inhibiting) | 7.8 | |
| RASSF4 | Ras association (RalGDS/AF-6) domain family 4 | 2.9 |
| PLEKHO1 | Pleckstrin homology domain containing, | 2.2 |
| WEE1 | WEE1 homolog (S. pombe) | 2.0 |
| MACF1 | Microtubule-actin cross-linking factor 1 | 2.0 |
| HGF | Hepatocyte growth factor (hepapoietin A; scatter factor) | 0.3 |
| Cell cycle (promoting) | ||
| STAG3 | Stromal antigen 3 | 3.9 |
| CYLD | Cylindromatosis (turban tumor syndrome) | 2.6 |
| TUBB2B | Tubulin, beta 2B | 2.4 |
| Gene ID . | Gene name . | Fold change . |
|---|---|---|
| Cell adhesion | ||
| IL32 | Interleukin 32 | 18.4 |
| CCL5 | Chemokine (C-C motif) ligand 5 | 17.8 |
| ICAM1 | Intercellular adhesion molecule 1 (CD54) | 13.5 |
| FBLN5 | Fibulin 5 | 6.3 |
| ITGB2 | Integrin, beta 2 (CD18) | 5.7 |
| ADAM8 | ADAM metallopeptidase domain 8 | 5.2 |
| ITGAM | Integrin, alpha M (CD11b) | 3.4 |
| FCGBP | Fc fragment of IgG binding protein | 3.3 |
| CD58 | CD58 molecule | 3.0 |
| Apoptosis (proapoptotic) | ||
| FAS | Fas (TNF receptor superfamily, member 6) | 29.7 |
| BTG1 | B-cell translocation gene 1 | 4.5 |
| PLAGL1 | Pleiomorphic adenoma gene-like 1 | 4.1 |
| IFIH1 | Interferon induced with helicase C domain 1 | 3.5 |
| BID | BH3 interacting domain death agonist | 2.3 |
| RUNX3 | Runt-related transcription factor 3 | 2.0 |
| ID3 | Inhibitor of DNA binding 3 | 0.5 |
| Apoptosis (antiapoptotic) | ||
| BCL2A1 | BCL2-related protein A1 | 84.2 |
| SGK1 | Serum/glucocorticoid regulated kinase 1 | 30.9 |
| TNFRSF9 | Tumor necrosis factor receptor superfamily, member 9 | 23.6 |
| TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | 17.1 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 6.7 |
| IL1B | Interleukin 1 beta | 6.3 |
| NUP62 | Nucleoporin 62 kDa | 5.1 |
| ATF5 | Activating transcription factor 5 | 3.7 |
| TRAF1 | TNF receptor-associated factor 1 | 3.0 |
| PIM1 | Pim-1 oncogene | 2.9 |
| IL2RA | Interleukin 2 receptor alpha | 2.7 |
| BIR3 | baculoviral IAP repeat-containing 3 | 2.6 |
| IER3 | Immediate early response 3 | 2.5 |
| BCL2 | B-cell CLL/lymphoma 2 | 2.5 |
| BCL3 | B-cell CLL/lymphoma 3 | 2.5 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 2.4 |
| NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 2.4 |
| NEK6 | NIMA (never in mitosis gene a)–related kinase 6 | 2.3 |
| BCL2L1 | BCL2-like 1 | 2.1 |
| Cell cycle (inhibiting) | 7.8 | |
| RASSF4 | Ras association (RalGDS/AF-6) domain family 4 | 2.9 |
| PLEKHO1 | Pleckstrin homology domain containing, | 2.2 |
| WEE1 | WEE1 homolog (S. pombe) | 2.0 |
| MACF1 | Microtubule-actin cross-linking factor 1 | 2.0 |
| HGF | Hepatocyte growth factor (hepapoietin A; scatter factor) | 0.3 |
| Cell cycle (promoting) | ||
| STAG3 | Stromal antigen 3 | 3.9 |
| CYLD | Cylindromatosis (turban tumor syndrome) | 2.6 |
| TUBB2B | Tubulin, beta 2B | 2.4 |
RNA from cells transfected with either pRTS-CA-IKK2 or pRTS-GFP and stimulated with doxycycline for 48 hours was analyzed by expression profiling. Genes were identified as differentially expressed if the ratio between the 2 classes was at least 2-fold. Biologic significance was determined using Gene Ontology.20