Distribution of concurrent integration sites of 34 FLT3-ITD– positive AML patients featuring multiple clones of various FLT3-ITD mutations
| . | JMD . | Hinge region of JMD . | Hinge region and NBL . | Beta1-sheet . | NBL . | Beta1- and beta2-sheet . | Beta2-sheet . |
|---|---|---|---|---|---|---|---|
| JMD | 6 | 8 | 1 | 9 | 2 | 2 | |
| Hinge region of JMD | 3 | 1 | 1 | ||||
| Beta1-sheet | 1 |
| . | JMD . | Hinge region of JMD . | Hinge region and NBL . | Beta1-sheet . | NBL . | Beta1- and beta2-sheet . | Beta2-sheet . |
|---|---|---|---|---|---|---|---|
| JMD | 6 | 8 | 1 | 9 | 2 | 2 | |
| Hinge region of JMD | 3 | 1 | 1 | ||||
| Beta1-sheet | 1 |
The localization of ITD integration sites and the respective frequencies are shown for 34 patients with different FLT3-ITD–mutated clones.
JMD indicates juxtamembrane domain; and NBL, nucleotide binding loop.