Patient demographics (n = 120)
| . | All patients . | MSI2 low (MSI2l) . | MSI2 high (MSI2h) . | P (MSI2l vs MSI2h) . |
|---|---|---|---|---|
| Medain age, y (range) | 55 (17-83) | 52.5 (17-83) | 61.5 (17-82) | .0756 |
| Sex | ||||
| Female | 62 | 46 | 16 | 1.000 |
| Male | 58 | 44 | 14 | |
| WBC at diagnosis, median (range) | 10 (0.1-366) | 10 (0.2-366) | 8.45 (0.1-337.1) | .6421 |
| FAB classification | ||||
| M0 | 7 | 6 | 1 | |
| M1 | 28 | 17 | 11 | |
| M2 | 38 | 26 | 12 | |
| M3 | 15 | 13 | 2 | .2867 |
| M4 | 15 | 14 | 1 | |
| M5 | 4 | 4 | 0 | |
| M6 | 1 | 0 | 1 | |
| M7 | 1 | 1 | 0 | |
| Not available | 11 | 9 | 2 | |
| Cytogenetics | ||||
| Good | 20 | 17 | 3 | |
| Intermediate | 62 | 43 | 19 | .2133 |
| Poor | 18 | 12 | 6 | |
| Not evaluated/not available | 20 | 18 | 2 |
| . | All patients . | MSI2 low (MSI2l) . | MSI2 high (MSI2h) . | P (MSI2l vs MSI2h) . |
|---|---|---|---|---|
| Medain age, y (range) | 55 (17-83) | 52.5 (17-83) | 61.5 (17-82) | .0756 |
| Sex | ||||
| Female | 62 | 46 | 16 | 1.000 |
| Male | 58 | 44 | 14 | |
| WBC at diagnosis, median (range) | 10 (0.1-366) | 10 (0.2-366) | 8.45 (0.1-337.1) | .6421 |
| FAB classification | ||||
| M0 | 7 | 6 | 1 | |
| M1 | 28 | 17 | 11 | |
| M2 | 38 | 26 | 12 | |
| M3 | 15 | 13 | 2 | .2867 |
| M4 | 15 | 14 | 1 | |
| M5 | 4 | 4 | 0 | |
| M6 | 1 | 0 | 1 | |
| M7 | 1 | 1 | 0 | |
| Not available | 11 | 9 | 2 | |
| Cytogenetics | ||||
| Good | 20 | 17 | 3 | |
| Intermediate | 62 | 43 | 19 | .2133 |
| Poor | 18 | 12 | 6 | |
| Not evaluated/not available | 20 | 18 | 2 |
There is no statistical difference in distribution of FAB subtypes and cytogenetic subgroups between MSI2 low and high cases.
MSI2 low indicates < 75th centile for total cellular MSI2 strong/3+ staining; and MSI2 high, ≥ 75th centile for total cellular MSI2 strong/3+ staining.