Features of A20 inactivation in ABC DLBCL and MCL
| . | ABC DLBCL . | MCL . |
|---|---|---|
| A20 mutation, n (%) | ||
| Total | 15/28 (53.5) | 3/18 (16.6) |
| With A20 deletion | 8/14 (57.1) | 1/7 (14.2) |
| Without A20 deletion | 7/14 (50) | 2/11 (18.1) |
| Promoter methylation, total, n (%) | 10/24 (41.6) | 3/8 (37.5) |
| A20 status, n (%) | ||
| Biallelic inactivation | 9/28 (32.1) | 3/18 (16.6) |
| Monoallelic inactivation | 13/28 (46.4) | 8/18 (44.4) |
| Intact | 6/28 (21.4) | 6/28 (21.4) |
| CARD11 mutation, n (%) | ||
| Total | 4/28 (14.2) | N.D. |
| With biallelic A20 inactivation | 0/9 (0) N.D. | |
| With monoallelic A20 inactivation | 2/13 (15.3) | N.D. |
| Without A20 inactivation | 2/6 (33.3) | N.D. |
| . | ABC DLBCL . | MCL . |
|---|---|---|
| A20 mutation, n (%) | ||
| Total | 15/28 (53.5) | 3/18 (16.6) |
| With A20 deletion | 8/14 (57.1) | 1/7 (14.2) |
| Without A20 deletion | 7/14 (50) | 2/11 (18.1) |
| Promoter methylation, total, n (%) | 10/24 (41.6) | 3/8 (37.5) |
| A20 status, n (%) | ||
| Biallelic inactivation | 9/28 (32.1) | 3/18 (16.6) |
| Monoallelic inactivation | 13/28 (46.4) | 8/18 (44.4) |
| Intact | 6/28 (21.4) | 6/28 (21.4) |
| CARD11 mutation, n (%) | ||
| Total | 4/28 (14.2) | N.D. |
| With biallelic A20 inactivation | 0/9 (0) N.D. | |
| With monoallelic A20 inactivation | 2/13 (15.3) | N.D. |
| Without A20 inactivation | 2/6 (33.3) | N.D. |
ND indicates not done.