Table 3 Myeloproliferative molecular... | American Society of Hematology

Table 3

Myeloproliferative molecular markers detected in granulocytes and in E-CFCs isolated from patients with MPN

Patient	Diagnosis	Thrombosis	Granulocytes			E-CFCs
Patient	Diagnosis	Thrombosis	JAK2	SOCS methylation	HUMARA	Colonies assayed	JAK2	SOCS methylation	HUMARA
1	PMF	No	wt	Yes	Polyclonal	20	wt	No	Polyclonal
2	PMF	No	V617F	No	NE	7	wt	No	NE
3	PMF	No	V617F	Yes	NE	2	wt	No	NE
4	PV	No	V617F	Yes	NE	3	wt	No	NE
5	ET	No	wt	Yes	NE	10	wt	No	NE
6	PMF	No	wt	Yes	NE	2	wt	No	NE
7	PMF	No	V617F	Yes	NE	14	wt	No	NE
8	ET	No	V617F	No	NE	3	wt	No	NE
9	ET	No	V617F	No	Clonal	7	wt	No	Polyclonal
10	PV	No	V617F	No	Clonal	5	wt	No	Polyclonal
11	PV	No	V617F	No	NE	11	wt	No	NE
12	PV	No	V617F	No	Clonal	2	wt	No	NE
13	ET	No	V617F	Yes	NE	1	wt	Yes	NE
14	PV	No	wt	Yes	NE	3	wt	Yes	NE
15	ET	No	V617F	Yes	Polyclonal	2	wt	Yes	NE
16	PMF	No	wt*	Yes	Clonal	5	wt*	Yes	Polyclonal
17	PMF	No	V617F	Yes	NE	4	wt	Yes	NE
18	PMF	PT	V617F	No	Clonal	21	V617F	No	Clonal
19	ET	BCS	V617F	No	Clonal	10	V617F	No	Clonal
20	PMF	PE, DVT	V617F	No	NE	2	V617F	No	NE
21	PMF	DVT	V617F	No	Clonal	6	V617F	No	Clonal
22	PV	Stroke	V617F	No	Clonal	10	V617F	No	Clonal

Patient	Diagnosis	Thrombosis	Granulocytes			E-CFCs
Patient	Diagnosis	Thrombosis	JAK2	SOCS methylation	HUMARA	Colonies assayed	JAK2	SOCS methylation	HUMARA
1	PMF	No	wt	Yes	Polyclonal	20	wt	No	Polyclonal
2	PMF	No	V617F	No	NE	7	wt	No	NE
3	PMF	No	V617F	Yes	NE	2	wt	No	NE
4	PV	No	V617F	Yes	NE	3	wt	No	NE
5	ET	No	wt	Yes	NE	10	wt	No	NE
6	PMF	No	wt	Yes	NE	2	wt	No	NE
7	PMF	No	V617F	Yes	NE	14	wt	No	NE
8	ET	No	V617F	No	NE	3	wt	No	NE
9	ET	No	V617F	No	Clonal	7	wt	No	Polyclonal
10	PV	No	V617F	No	Clonal	5	wt	No	Polyclonal
11	PV	No	V617F	No	NE	11	wt	No	NE
12	PV	No	V617F	No	Clonal	2	wt	No	NE
13	ET	No	V617F	Yes	NE	1	wt	Yes	NE
14	PV	No	wt	Yes	NE	3	wt	Yes	NE
15	ET	No	V617F	Yes	Polyclonal	2	wt	Yes	NE
16	PMF	No	wt*	Yes	Clonal	5	wt*	Yes	Polyclonal
17	PMF	No	V617F	Yes	NE	4	wt	Yes	NE
18	PMF	PT	V617F	No	Clonal	21	V617F	No	Clonal
19	ET	BCS	V617F	No	Clonal	10	V617F	No	Clonal
20	PMF	PE, DVT	V617F	No	NE	2	V617F	No	NE
21	PMF	DVT	V617F	No	Clonal	6	V617F	No	Clonal
22	PV	Stroke	V617F	No	Clonal	10	V617F	No	Clonal

wt indicates wild type; NE, not evaluable; PT, portal vein thrombosis; BCS, Budd-Chiari syndrome; PE, pulmonary embolism; and DVT, deep vein thrombosis of the legs.

This patient carried the MPL^K515L mutation.

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